UBE3A and ZNF250

Number of citations of the paper that reports this interaction (PubMedID 29426014)
4

Data Source:
BioGRID (two hybrid)

		UBE3A	ZNF250
Description		ubiquitin protein ligase E3A	zinc finger protein 250
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Cell Nucleus Cytosol	Nucleus
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	DNA Binding Metal Ion Binding
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Regulation Of Transcription, DNA-templated
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Generic Transcription Pathway
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Logical memory (immediate recall) in normal cognition ( 29274321)
Interacting Genes		121 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MCM6 MCM7 MDM1 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PSMD4 PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446	47 interacting genes: BEGAIN CARD9 CCDC102B CCDC136 CCDC85B CDCA7L CEP44 DPPA2 DVL2 FAM124A GMCL1 GNPTAB GOLGA2 HEXIM2 HOOK1 HOOK2 KASH5 KRT40 KRTAP10-3 KRTAP10-7 KRTAP4-12 LDOC1 LZTS2 MAGOHB MID2 MTUS2 NINL PLEKHF2 PRPF31 SSX2IP SYNE4 TFF1 TMCC2 TNNT1 TNS2 TRAF1 TRIM23 TRIM27 TRIM41 TRIM54 UBE3A ZBTB8A ZC4H2 ZNF165 ZNF175 ZNF460 ZNF473
Entrez ID		7337	58500
HPRD ID		03375	15758
Ensembl ID		ENSG00000114062	ENSG00000196150
Uniprot IDs		Q05086 Q9H2G0	B3KNS9 P15622
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV
Enriched GO Terms of Interacting Partners?
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