TP53BP2 and HNRNPUL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TP53BP2	HNRNPUL1
Description		tumor protein p53 binding protein 2	heterogeneous nuclear ribonucleoprotein U like 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm
	Molecular Function	P53 Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding	RNA Binding Protein Binding Enzyme Binding
	Biological Process	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator	MRNA Splicing, Via Spliceosome RNA Processing Response To Virus
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors	mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Triptolide cytotoxicity ( 26121980)	Heel bone mineral density ( 28869591) Urinary albumin-to-creatinine ratio ( 31511532)
Interacting Genes		64 interacting genes: APP ATPAF2 ATXN7 AXIN1 BAIAP2 BCL2 BCL2L1 CCDC92 CRK CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 H2BC4 HIF1AN HNRNPUL1 HYOU1 KIF5A LHX4 LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NFKB1 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CC PRKAB2 PRPF31 PTN RELA RXRB SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UBE3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26	47 interacting genes: BRD7 CRMP1 DMRTB1 DZIP3 EP300 ERG ERG28 EWSR1 GIT2 HNRNPF HNRNPH2 HNRNPH3 IL7R ITCH MAPK1IP1L MARS1 MED31 NEDD4 NXF1 NXF2 NXF3 PIAS4 PPIL1 PRMT1 PRMT2 PRPF40A RBM22 RBM4 RBM4B ROPN1 RPA1 RPA2 SF1 SF3B4 SMN1 SMN2 SNRPB2 SNRPC SORBS3 SRSF9 TGM2 TLX3 TP53 TP53BP2 VPS37C WWP2 ZNF207
Entrez ID		7159	11100
HPRD ID		11803	10428
Ensembl ID		ENSG00000143514	ENSG00000105323
Uniprot IDs		Q13625	A0A024R0J9 A0A0A0MRA5 A8K3W4 B7Z4B8 Q9BUJ2
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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