UBE3A and JADE1

Number of citations of the paper that reports this interaction (PubMedID 16713569)
313

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)
HPRD (two hybrid)

		UBE3A	JADE1
Description		ubiquitin protein ligase E3A	jade family PHD finger 1
Image			No pdb structure
GO Annotations	Cellular Component	Proteasome Complex Cell Nucleus Cytosol	Histone Acetyltransferase Complex Nucleus Nucleoplasm Cytoplasm Plasma Membrane Nuclear Speck Ciliary Basal Body
	Molecular Function	Transcription Coactivator Activity Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Transcription Coactivator Activity Protein Binding Metal Ion Binding
	Biological Process	Ovarian Follicle Development Proteolysis Ubiquitin-dependent Protein Catabolic Process Brain Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Viral Process Androgen Receptor Signaling Pathway Positive Regulation Of Protein Ubiquitination Response To Progesterone Sperm Entry Response To Cocaine Response To Hydrogen Peroxide Regulation Of Circadian Rhythm Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Progesterone Receptor Signaling Pathway Protein Autoubiquitination Prostate Gland Growth Negative Regulation Of Dendritic Spine Morphogenesis Protein K48-linked Ubiquitination Positive Regulation Of Golgi Lumen Acidification Cellular Response To Brain-derived Neurotrophic Factor Stimulus Regulation Of Ubiquitin-dependent Protein Catabolic Process	Apoptotic Process Negative Regulation Of Cell Growth Histone H3 Acetylation Histone H4-K5 Acetylation Histone H4-K8 Acetylation Histone H4-K12 Acetylation Histone H4-K16 Acetylation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Nucleic Acid-templated Transcription Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	HATs acetylate histones
Drugs
Diseases		Prader-Willi and Angelman syndromes, including: Angelman syndrome (AS); Prader-Willi syndrome (PWS)
GWAS		Cardiac hypertrophy ( 21348951) Gene methylation in lung tissue ( 25713168) Obesity-related traits ( 23251661)	Arterial stiffness index ( 31235810) Bone mineral density (total hip) ( 29883787)
Interacting Genes		121 interacting genes: ACTA2 ACTB ACTBL2 ACTR3 ADRM1 AFG3L1P AFTPH AHSP ANXA1 APP AR ARC ARHGDIB ASAP3 ATG9A BARD1 BLK BPY2 BPY2B BPY2C BRCA1 C11orf49 CALR CDK1 CDK4 CDKN1B CEBPZ CGGBP1 CTNNB1 DAZAP2 DLG1 E2F1 EAPP EID1 EIF4G1 FAF2 GFAP GTF3C1 HBA1 HPCAL4 HSP90AB1 HSPA4 HSPA5 JADE1 KLHL38 KRT1 KRT5 KRT7 KRT9 LCK MAGEA12 MAGEA8 MAPK1 MCM6 MCM7 MDM1 MDM2 MEOX2 NDUFA13 NELFCD NOMO2 PARVA PAX5 PAX6 PDE1B PDIA3 PDIA6 PGR PML POLE4 PRAG1 PRDX1 PRKACA PRMT5 PSAP PSMD4 PTCD3 RAD23A RAD23B RARA RMI1 RPS15A RYBP SACS SCAMP1 SCRIB SHBG SIRT6 SMAD9 SOD1 SPINK1 SUMO3 TALDO1 TAT TBC1D14 TCF19 TP53 TP53BP2 TRIM65 TSC2 TTC23L TTC3 UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2G1 UBE2G2 UBE2L3 UBE2L6 UBE2N UBQLN1 UBQLN2 WBP2 YOD1 YWHAE YWHAG YWHAZ ZNF250 ZNF446	15 interacting genes: AKT1 AP2M1 CTNNB1 H3C14 H4C1 HMOX2 PFDN1 SEPTIN8 SMN1 TK1 UBE2E1 UBE2H UBE3A VHL YJU2
Entrez ID		7337	79960
HPRD ID		03375	10151
Ensembl ID		ENSG00000114062	ENSG00000077684
Uniprot IDs		Q05086 Q9H2G0	B4E2E2 Q6IE81
PDB IDs		1C4Z 1D5F 1EQX 2KR1 4GIZ 4XR8 6SJV
Enriched GO Terms of Interacting Partners?
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