TP53BP2 and PLEKHN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TP53BP2	PLEKHN1
Description		tumor protein p53 binding protein 2	pleckstrin homology domain containing N1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Cell Junction Perinuclear Region Of Cytoplasm	Mitochondrion Cytoskeleton Plasma Membrane Mitochondrial Membrane
	Molecular Function	P53 Binding SH3/SH2 Adaptor Activity Protein Binding SH3 Domain Binding Identical Protein Binding NF-kappaB Binding	Phosphatidylserine Binding Protein Binding Phosphatidic Acid Binding Cardiolipin Binding Phosphatidylinositol Phosphate Binding
	Biological Process	Cell Cycle Signal Transduction Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Execution Phase Of Apoptosis Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Positive Regulation Of Neuron Death Regulation Of Signal Transduction By P53 Class Mediator	Response To Hypoxia Positive Regulation Of Apoptotic Process 3'-UTR-mediated MRNA Destabilization
Pathways		Activation of PUMA and translocation to mitochondria TP53 Regulates Transcription of Genes Involved in Cytochrome C Release TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain TP53 Regulates Transcription of Death Receptors and Ligands Regulation of TP53 Activity through Association with Co-factors
Drugs
Diseases
GWAS		Triptolide cytotoxicity ( 26121980)	Height ( 31562340) Parkinson's disease ( 26227905)
Interacting Genes		64 interacting genes: APP ATPAF2 ATXN7 AXIN1 BAIAP2 BCL2 BCL2L1 CCDC92 CRK CSNK2B CWF19L2 DCUN1D1 EEF1A1 GRB2 H2BC4 HIF1AN HNRNPUL1 HYOU1 KIF5A LHX4 LMO4 MAGI1 MAPK8IP2 MRPL20 MTMR14 NAE1 NDC80 NFKB1 NUTM1 OTUB2 PLEKHN1 PLK1 POLR2L PPHLN1 PPP1CA PPP1CC PRKAB2 PRPF31 PTN RELA RXRB SIAH1 SIAH2 SUMO2 SUMO3 TANK TBC1D22B TCL1A TP53 TRAF4 TXLNA UBASH3A UBE3A UNC119 USP4 UTP14A WWP1 WWP2 YAP1 YES1 YWHAG YWHAQ ZGPAT ZNF26	11 interacting genes: CBY2 LPXN LZTS2 PUSL1 REL RFX6 TAX1BP1 TCF4 TP53BP2 TRAF1 TRIM27
Entrez ID		7159	84069
HPRD ID		11803	13190
Ensembl ID		ENSG00000143514	ENSG00000187583
Uniprot IDs		Q13625	Q494U1
PDB IDs		1YCS 2UWQ 4A63 4IRV 6GHM 6HKP
Enriched GO Terms of Interacting Partners?
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