TNNT2 and NOTCH3

Number of citations of the paper that reports this interaction (PubMedID 25356737)
12

Data Source:
BioGRID (pull down)

		TNNT2	NOTCH3
Description		troponin T2, cardiac type	notch receptor 3
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GO Annotations	Cellular Component	Cytosol Troponin Complex Striated Muscle Thin Filament Sarcomere Cardiac Myofibril Cardiac Troponin Complex	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex
	Molecular Function	Actin Binding Calcium Ion Binding Protein Binding Tropomyosin Binding Troponin C Binding Calcium-dependent ATPase Activity Troponin I Binding	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding
	Biological Process	Skeletal Muscle Contraction Muscle Contraction Regulation Of Muscle Contraction Regulation Of Heart Contraction Muscle Filament Sliding Negative Regulation Of ATPase Activity Positive Regulation Of ATPase Activity Sarcomere Organization Response To Calcium Ion Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Forebrain Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Glomerular Capillary Formation
Pathways		Striated Muscle Contraction	Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases		Hypertrophic cardiomyopathy (HCM) Dilated cardiomyopathy (DCM)	Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Cardiac Troponin-T levels ( 23247143) Height ( 28552196) Neurofibrillary tangles ( 25188341)	Pulse pressure ( 27841878 30578418)
Interacting Genes		11 interacting genes: APP KDM1A MAP3K5 MORF4L2 MST1 NOTCH3 PRKCA TNNC1 TNNI1 TNNI3 TPM1	43 interacting genes: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 UPF1 WDR25 XKR8
Entrez ID		7139	4854
HPRD ID		01844	02607
Ensembl ID		ENSG00000118194	ENSG00000074181
Uniprot IDs		A0A0A0MRJ5 P45379 Q15607	Q9UM47
PDB IDs		1J1D 1J1E 4Y99	4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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