NOTCH3 and TMEM108

Number of citations of the paper that reports this interaction (PubMedID 25356737)
12

Data Source:
BioGRID (pull down)

		NOTCH3	TMEM108
Description		notch receptor 3	transmembrane protein 108
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex	Cellular_component Early Endosome Endosome Membrane Postsynaptic Density Integral Component Of Membrane Cell Junction Axon Dendrite Somatodendritic Compartment Axon Cytoplasm
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Molecular_function
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Forebrain Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Glomerular Capillary Formation	Receptor-mediated Endocytosis Retrograde Axonal Transport Biological_process Dentate Gyrus Development Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Postsynaptic Density Organization Dendrite Extension Modulation Of Excitatory Postsynaptic Potential Cellular Response To Brain-derived Neurotrophic Factor Stimulus
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418)	Chronotype ( 30696823) IgE grass sensitization ( 22036096) Iron status biomarkers (total iron binding capacity) ( 28334935) Menarche (age at onset) ( 27182965 21102462) Systolic blood pressure ( 30224653 30578418) Waist circumference ( 28552196)
Interacting Genes		43 interacting genes: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 UPF1 WDR25 XKR8	4 interacting genes: ANXA7 ARHGEF6 NOTCH3 SH3GL2
Entrez ID		4854	66000
HPRD ID		02607	11329
Ensembl ID		ENSG00000074181	ENSG00000144868
Uniprot IDs		Q9UM47	B3KT64 Q6UXF1
PDB IDs		4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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