NOTCH3 and EGFL7

Number of citations of the paper that reports this interaction (PubMedID 19503073)
52

Data Source:
BioGRID (two hybrid)

		NOTCH3	EGFL7
Description		notch receptor 3	EGF like domain multiple 7
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Region Nucleoplasm Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Cell Surface Actin Cytoskeleton Integral Component Of Membrane Receptor Complex	Extracellular Region Extracellular Space Cell Surface Collagen-containing Extracellular Matrix
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Binding Signaling Receptor Activity Identical Protein Binding Cadherin Binding	Signaling Receptor Binding Calcium Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Notch Signaling Pathway Positive Regulation Of Transcription Of Notch Receptor Target Forebrain Development Negative Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Neuron Fate Commitment Artery Morphogenesis Glomerular Capillary Formation	Angiogenesis Blood Vessel Development Vasculogenesis Positive Regulation Of Endothelial Cell Proliferation Cell Adhesion Negative Regulation Of Notch Signaling Pathway Anatomical Structure Development
Pathways		Pre-NOTCH Processing in the Endoplasmic Reticulum Pre-NOTCH Transcription and Translation Pre-NOTCH Processing in Golgi Pre-NOTCH Processing in Golgi Notch-HLH transcription pathway Defective LFNG causes SCDO3 NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Activation and Transmission of Signal to the Nucleus NOTCH3 Intracellular Domain Regulates Transcription NOTCH3 Intracellular Domain Regulates Transcription Noncanonical activation of NOTCH3
Drugs
Diseases		Cerebral autosomal dominant arteriopathy with subcortical infarcts and leucoencephalopathy (CADASIL)
GWAS		Pulse pressure ( 27841878 30578418)	Diastolic blood pressure ( 30224653) Lean body mass ( 28552196) Metabolite levels ( 23823483) Triiodothyronine levels and thyroxine levels ( 30843173)
Interacting Genes		43 interacting genes: BAG2 BTF3L4 C1QL1 C8orf76 CBFA2T2 CHUK CNTD1 CPNE6 CRIP2 CSNK2B DLL1 EGFL7 FBLN1 GGT6 JAG1 JAG2 KAT2B LINC00839 MAML1 MAML2 MAML3 MPPED2 MTDH MYC NEDD9 PPIA PSEN1 PSEN2 RBPJ RET RMI2 SCGB3A1 SLC39A1 SNW1 SNX19 SORBS3 SPTLC2 TMEM108 TNNT2 TPT1 UPF1 WDR25 XKR8	6 interacting genes: GFI1B NOTCH1 NOTCH2 NOTCH3 NOTCH4 SMARCD1
Entrez ID		4854	51162
HPRD ID		02607	16351
Ensembl ID		ENSG00000074181	ENSG00000172889
Uniprot IDs		Q9UM47	A0A024R8F5 Q9UHF1
PDB IDs		4ZLP 5CZV 5CZX
Enriched GO Terms of Interacting Partners?
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