EMX2 and MEIS1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		EMX2	MEIS1
Description		empty spiracles homeobox 2	Meis homeobox 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Nuclear Chromatin Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Neuron Differentiation Response To Drug Ureter Morphogenesis	Angiogenesis Lens Morphogenesis In Camera-type Eye Locomotory Behavior Megakaryocyte Development Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cardiac Muscle Cell Proliferation Definitive Hemopoiesis
Pathways			Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Celiac disease ( 23936387) Chronotype ( 30696823) Double-edged eyelids ( 29895819) Early cardiac repolarization ( 22683750) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Low tan response ( 29739929) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Pulmonary function in asthmatics ( 23541324) Response to quetiapine in schizophrenia ( 29503163) Serum uric acid levels ( 30993211 29403010) Skin pigmentation ( 30664655) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Urate levels ( 31578528)	Adolescent idiopathic scoliosis ( 28334814) Chronotype ( 30696823) Coffee consumption ( 31046077) Colorectal cancer (diet interaction) ( 24743840) Early spontaneous preterm birth ( 31194736) Endometriosis ( 27506219) Glaucoma (primary open-angle) ( 29891935) HDL cholesterol ( 30275531) Heel bone mineral density ( 30598549) Height ( 28552196) Insomnia ( 27992416) Insomnia complaints ( 28604731) Insomnia complaints (continuous) ( 28604731) Insomnia complaints (dichotomous) ( 28604731) Insomnia symptoms (never/rarely vs. sometimes/usually) ( 30804566) Insomnia symptoms (never/rarely vs. usually) ( 30804566) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Morning person ( 30696823) Photic sneeze reflex ( 27182965) PR interval ( 30679814 30046033 20062060 23139255 21347284) PR segment ( 24850809) Relative amplitude of rest-activity cycles ( 30120083) Resting heart rate ( 27798624) Restless legs syndrome ( 17637780 29029846 21779176) Sleep duration ( 30531941) Sleep traits (multi-trait analysis) ( 27992416) Systolic blood pressure ( 30224653 30578418) Triglycerides ( 30275531) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI (joint analysis for main effect and physical activity interaction) ( 28448500) Waist-to-hip ratio adjusted for BMI in active individuals ( 28448500) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971) Waist-to-hip ratio adjusted for body mass index ( 25673412 28448500)
Interacting Genes		4 interacting genes: EIF4E GTF2A1L MEIS1 TLE2	27 interacting genes: EMX2 ETS1 HOXA10 HOXA11 HOXA13 HOXA2 HOXA5 HOXA7 HOXA9 HOXB1 HOXB13 HOXB4 HOXB8 HOXC11 HOXC13 HOXD11 HOXD12 HOXD13 HOXD4 HOXD9 PBX1 PBX3 PKNOX1 TLX1 TLX2 TLX3 TRMT10B
Entrez ID		2018	4211
HPRD ID		02495	03442
Ensembl ID		ENSG00000170370	ENSG00000143995
Uniprot IDs		Q04743	O00470
PDB IDs			4XRS 5EGO
Enriched GO Terms of Interacting Partners?
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