EMX2 and TLE2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		EMX2	TLE2
Description		empty spiracles homeobox 2	TLE family member 2, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus	Extracellular Space Nucleus Nucleoplasm Transcription Factor Complex Focal Adhesion Nuclear Body
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Intronic Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding	Transcription Corepressor Activity Protein Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Brain Development Anterior/posterior Pattern Specification Dentate Gyrus Development Cerebral Cortex Regionalization Cell Proliferation In Forebrain Forebrain Cell Migration Neuron Differentiation Response To Drug Ureter Morphogenesis	Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Canonical Wnt Signaling Pathway Beta-catenin-TCF Complex Assembly
Pathways			Formation of the beta-catenin:TCF transactivating complex NOTCH1 Intracellular Domain Regulates Transcription Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes
Drugs
Diseases
GWAS		Airflow obstruction ( 22837378) Celiac disease ( 23936387) Chronotype ( 30696823) Double-edged eyelids ( 29895819) Early cardiac repolarization ( 22683750) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Low tan response ( 29739929) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Ovarian disease with few adhesions ( 28333195) Photic sneeze reflex ( 27182965) Pulmonary function in asthmatics ( 23541324) Response to quetiapine in schizophrenia ( 29503163) Serum uric acid levels ( 30993211 29403010) Skin pigmentation ( 30664655) Skin, hair and eye pigmentation (multivariate analysis) ( 30664655) Urate levels ( 31578528)
Interacting Genes		4 interacting genes: EIF4E GTF2A1L MEIS1 TLE2	16 interacting genes: BARHL1 EMX2 FOXA3 H3-3A HES1 HMGB1 LEF1 MSX1 MSX2 PAX9 PRDM1 RUNX1 TLE1 TLX3 UTY VENTX
Entrez ID		2018	7089
HPRD ID		02495	03025
Ensembl ID		ENSG00000170370	ENSG00000065717
Uniprot IDs		Q04743	K7EMK7 Q04725
PDB IDs
Enriched GO Terms of Interacting Partners?
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