PLEC and MAP2

Number of citations of the paper that reports this interaction (PubMedID 3027087)
37

Data Source:
HPRD (in vitro)

		PLEC	MAP2
Description		plectin	microtubule associated protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Intermediate Filament Plasma Membrane Brush Border Focal Adhesion Membrane Sarcoplasm Hemidesmosome Sarcolemma Costamere Intermediate Filament Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome	Cytoplasm Cytosol Microtubule Microtubule Associated Complex Postsynaptic Density Dendrite Dendrite Cytoplasm Nuclear Periphery Neuron Projection Neuronal Cell Body Axon Initial Segment Dendritic Shaft Axon Hillock Dendritic Growth Cone Main Axon Dendritic Branch Basal Dendrite CA3 Pyramidal Cell Dendrite Primary Dendrite Distal Dendrite Apical Distal Dendrite Dendritic Filopodium Proximal Dendrite Proximal Neuron Projection
	Molecular Function	RNA Binding Actin Binding Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Muscle Ankyrin Binding Cadherin Binding	Dystroglycan Binding Structural Molecule Activity Protein Binding Calmodulin Binding Microtubule Binding Tau Protein Binding
	Biological Process	Hemidesmosome Assembly Wound Healing Intermediate Filament Cytoskeleton Organization	Microtubule Cytoskeleton Organization Microtubule Bundle Formation Axonogenesis Dendrite Development Central Nervous System Neuron Development Establishment Of Cell Polarity Negative Regulation Of Axon Extension Regulation Of Microtubule Polymerization Negative Regulation Of Microtubule Polymerization Neuron Projection Development Dendrite Morphogenesis Cellular Response To Organic Substance Positive Regulation Of Anterograde Dense Core Granule Transport Regulation Of Organelle Transport Along Microtubule Positive Regulation Of Anterograde Synaptic Vesicle Transport Regulation Of Cellular Protein Localization Negative Regulation Of Microtubule Binding Negative Regulation Of Microtubule Motor Activity
Pathways		Assembly of collagen fibrils and other multimeric structures Caspase-mediated cleavage of cytoskeletal proteins Type I hemidesmosome assembly
Drugs			Estramustine Paclitaxel Docetaxel
Diseases		Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy Epidermolysis bullosa, hemidesmosomal, including: Epidermolysis bullosa, generalized atrophic benign (GABEB); Epidermolysis bullosa simplex with pyloric atresia (EBS-PA); Epidermolysis bullosa simplex with muscular dystrophy (EBS-MD); Epidermolysis bullosa simplex, Ogna type (EBS-Ogna)
GWAS		Anti-saccade response ( 29064472) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Diastolic blood pressure ( 30224653) Fibrinogen levels ( 28107422 26561523) Height ( 31562340) Knee osteoarthritis ( 28916551) LDL cholesterol ( 30275531) Mean platelet volume ( 27863252) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mosquito bite size ( 28199695) Platelet count ( 27863252) Platelet distribution width ( 27863252) Plateletcrit ( 27863252) Post bronchodilator FEV1 ( 26634245) Resting heart rate ( 27798624) Total cholesterol levels ( 30275531)	Adventurousness ( 30643258) Bipolar disorder ( 31043756) Body mass index ( 28552196) General risk tolerance (MTAG) ( 30643258) Handedness (Left-handed vs. non-left-handed) ( 31504236 30980028) Handedness (left-handed vs. right-handed) ( 31504236) Height ( 28552196)
Interacting Genes		22 interacting genes: ACTC1 ACTG1 ANK3 BRCA2 CASP8 CDK1 COL17A1 EGFR ITGA6 ITGB4 LMNB1 MAP2 MSN MTDH PLEKHA5 PTEN RACK1 SMAD9 SPTA1 SPTAN1 UBC VIM	26 interacting genes: ACSL3 ACTB ACTN1 APOE APP CPEB1 DAG1 FYN GRB2 GRIN1 GRIN2D JUNB MARK1 MARK3 MARK4 MDM2 MYO7A NEDD4L NEFL PAFAH1B1 PLEC PRKACA PRKAR2A SRC TTBK1 TUBA1A
Entrez ID		5339	4133
HPRD ID		03180	01140
Ensembl ID		ENSG00000178209	ENSG00000078018
Uniprot IDs		Q15149	A0A024R3Y8 A0A024R3Z1 A0A024R409 P11137 Q6NYC5
PDB IDs		1MB8 2N03 2ODU 2ODV 3F7P 3PDY 3PE0 4GDO 4Q58 4Q59 5J1F 5J1G 5J1H 5J1I
Enriched GO Terms of Interacting Partners?
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