TCF12 and FRMD6

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		TCF12	FRMD6
Description		transcription factor 12	FERM domain containing 6
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytoplasm Nuclear Speck Intracellular Membrane-bounded Organelle RNA Polymerase II Transcription Factor Complex	Cytoplasm Cytoskeleton Plasma Membrane Apical Junction Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Transcription Factor Binding Enhancer Binding CAMP Response Element Binding Protein Homodimerization Activity BHLH Transcription Factor Binding Transcription Regulatory Region DNA Binding SMAD Binding Protein Heterodimerization Activity E-box Binding HMG Box Domain Binding	Protein Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Immune Response Muscle Organ Development Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Hematopoietic Stem Cell Differentiation	Apical Constriction Actomyosin Structure Organization Regulation Of Actin Filament-based Process Cellular Protein Localization
Pathways		Myogenesis Myogenesis RUNX1 regulates transcription of genes involved in differentiation of HSCs NGF-stimulated transcription NGF-stimulated transcription
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alcohol consumption (drinks per week) ( 30643258) Body mass index ( 28892062) Glaucoma (primary open-angle) ( 29891935) Male-pattern baldness ( 28196072) Mean platelet volume ( 27863252) Type 2 diabetes ( 30297969)	Anticoagulant levels ( 22216198) Brain structure ( 20171287) Cognitive decline rate in late mild cognitive impairment ( 26252872) Hippocampal atrophy ( 19668339) Lung cancer (smoking interaction) ( 24658283) Multiple sclerosis ( 31604244) Nonsyndromic cleft lip with or without cleft palate ( 28087736) Total ventricular volume ( 21116278) Triglyceride levels x loop diuretics use interaction ( 31806883)
Interacting Genes		59 interacting genes: ACTB ADAM10 ARMC8 ASCL4 BCL2L10 BMERB1 BMF C1orf109 CDKN2C CFAP206 CRCP CREBBP DGCR6 EDRF1 EP300 FRMD6 HAND1 HOPX ID1 ID2 ID3 LYSMD1 MAPK6 MAPKBP1 MLLT6 MORN4 MSC MYF6 NAGK OLIG3 OSGIN1 PRSS23 PSMA1 PTF1A QARS1 RNASEL RSL24D1 RUNX1T1 SCG3 SLC12A1 SLC24A1 SOX10 SOX8 SPG21 SPTBN5 SRI STAT5A STK16 TAF4 TAL2 TBP TCF23 TCF3 TRIM72 TSNAX TWIST2 VPS28 YKT6 ZNF688	20 interacting genes: - BLZF1 COX6B2 DNAJA3 EXOC5 GMCL1 HMBOX1 IKZF1 JMJD6 LZTS2 MED4 MID2 MLH1 RASSF8 SSX2IP SUV39H1 TCF12 TSC22D4 WDR7 YWHAB
Entrez ID		6938	122786
HPRD ID		02725	12646
Ensembl ID		ENSG00000140262	ENSG00000139926
Uniprot IDs		A0A024R5T1 A0A024R5Z0 F5GY10 Q99081	Q96NE9
PDB IDs		2KNH 4JOL
Enriched GO Terms of Interacting Partners?
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