SP4 and COL8A1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SP4	COL8A1
Description		Sp4 transcription factor	collagen type VIII alpha 1 chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol	Extracellular Region Collagen Type VIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleic Acid-templated Transcription	Angiogenesis Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Camera-type Eye Morphogenesis Epithelial Cell Proliferation
Pathways			Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Acute lymphoblastic leukemia (childhood) ( 29348612) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756) General cognitive ability ( 29844566) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636) Axial length ( 24144296) Childhood ear infection ( 27182965) Cleft lip with or without cleft palate ( 28054174) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 31798171 25241763 28073927)
Interacting Genes		16 interacting genes: - ADAM15 ATXN7L1 BANP CIB3 COL8A1 E2F1 FOXP2 LMO3 NKX3-1 NRF1 POU2F1 PRR20A SERF2 SP1 ZBTB7A	20 interacting genes: ADAMTSL4 COL8A2 CREB5 EFEMP2 INCA1 ITGA1 ITGA2 KLHL12 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP26-1 KRTAP4-12 KRTAP9-2 NOTCH2NLA REL SP4 UBQLN4 VAC14
Entrez ID		6671	1295
HPRD ID		02764	00372
Ensembl ID		ENSG00000105866	ENSG00000144810
Uniprot IDs		A0A3B3IRW4 Q02446 Q32M51	P27658
PDB IDs
Enriched GO Terms of Interacting Partners?
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