COL8A1 and SP4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		COL8A1	SP4
Description		collagen type VIII alpha 1 chain	Sp4 transcription factor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Nuclear Chromatin Nucleus Nucleoplasm Cytosol
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Transcription Coactivator Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Angiogenesis Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Camera-type Eye Morphogenesis Epithelial Cell Proliferation	Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleic Acid-templated Transcription
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636) Axial length ( 24144296) Childhood ear infection ( 27182965) Cleft lip with or without cleft palate ( 28054174) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 31798171 25241763 28073927)	Acute lymphoblastic leukemia (childhood) ( 29348612) Amyotrophic lateral sclerosis (sporadic) ( 24529757) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Bipolar disorder ( 31043756) General cognitive ability ( 29844566) Major depressive disorder ( 20125088) Major depressive disorder (broad) ( 20038947) Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) ( 23103227) Multisite chronic pain ( 31194737) Schizophrenia ( 30285260) Temporomandibular joint disorder ( 28081371)
Interacting Genes		20 interacting genes: ADAMTSL4 COL8A2 CREB5 EFEMP2 INCA1 ITGA1 ITGA2 KLHL12 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP26-1 KRTAP4-12 KRTAP9-2 NOTCH2NLA REL SP4 UBQLN4 VAC14	16 interacting genes: - ADAM15 ATXN7L1 BANP CIB3 COL8A1 E2F1 FOXP2 LMO3 NKX3-1 NRF1 POU2F1 PRR20A SERF2 SP1 ZBTB7A
Entrez ID		1295	6671
HPRD ID		00372	02764
Ensembl ID		ENSG00000144810	ENSG00000105866
Uniprot IDs		P27658	A0A3B3IRW4 Q02446 Q32M51
PDB IDs
Enriched GO Terms of Interacting Partners?
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