SNCA and GAPDH

Number of citations of the paper that reports this interaction (PubMedID 15673432)
19

Data Source:
BioGRID (pull down)

		SNCA	GAPDH
Description		synuclein alpha	glyceraldehyde-3-phosphate dehydrogenase
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Inclusion Body Cell Junction Axon Growth Cone Platelet Alpha Granule Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Presynapse Supramolecular Fiber	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Nuclear Membrane Vesicle Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Extracellular Exosome GAIT Complex Ribonucleoprotein Complex
	Molecular Function	SNARE Binding Magnesium Ion Binding Actin Binding Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding Tau Protein Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity Dynein Complex Binding Cuprous Ion Binding	Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (phosphorylating) Activity Protein Binding Microtubule Binding Aspartic-type Endopeptidase Inhibitor Activity Peptidyl-cysteine S-nitrosylase Activity Identical Protein Binding NADP Binding NAD Binding Disordered Domain Specific Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Receptor Recycling Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Regulation Of Transmembrane Transporter Activity Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation SNARE Complex Assembly Positive Regulation Of SNARE Complex Assembly Dopamine Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Inflammatory Response Protein Tetramerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Norepinephrine Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Oxidation-reduction Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Presynapse Assembly	Microtubule Cytoskeleton Organization Gluconeogenesis Glycolytic Process Negative Regulation Of Endopeptidase Activity Regulation Of Macroautophagy Negative Regulation Of Translation Killing Of Cells Of Other Organism Peptidyl-cysteine S-trans-nitrosylation Positive Regulation Of Cytokine Secretion Protein Stabilization Defense Response To Fungus Neuron Apoptotic Process Killing By Host Of Symbiont Cells Positive Regulation By Organism Of Apoptotic Process In Other Organism Involved In Symbiotic Interaction Canonical Glycolysis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Cellular Response To Interferon-gamma
Pathways		Amyloid fiber formation	Glycolysis Gluconeogenesis
Drugs		Resveratrol Copper	NADH Adenosine-5-Diphosphoribose Thionicotinamide-Adenine-Dinucleotide 4-(2-Aminoethyl)Benzenesulfonyl Fluoride Xanthinol Copper
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Blood protein levels ( 30072576 29875488) Dementia with Lewy bodies ( 29263008) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling nervous ( 29500382) Neurociticism ( 29500382) Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 25064009 31660654 27182965 28892059 22438815 28011712 20070850 21044948 24511991 21738487) Parkinson's disease (age of onset) ( 31660654 30957308) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to bupropion in depression ( 27622933)	Blood protein levels ( 30072576)
Interacting Genes		123 interacting genes: A1BG ACTA1 ADAP2 AKT1 AMBRA1 ANXA6 APLP1 APP ARHGAP15 ARPP19 BAD BAG5 BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 COL25A1 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CTSD CYCS DMTN DNAJC5 DOCK7 DYRK1A EEF1A1 EGFR EIF3G ELK1 ENC1 ENSA FBXL5 FGR FKBP4 FYN GABARAPL1 GAPDH GBA GRK1 GRK2 GRK5 GRK6 GSK3B H1-1 H1-2 HSD17B4 HSP90AA1 HSPA1A HSPA8 HSPB1 HSPB2 HSPB6 HSPB8 IARS1 KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D MT-CO1 MT-CO3 NEDD4 NEDD4L PAK3 PDE4DIP PDIA2 PELP1 PFDN2 PLCB2 PLD1 PLK1 PLK2 PLK3 PRDX1 PREP PRKCE PRKN PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPTIN4 SIAH2 SLC6A3 SMURF2 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI STAMBP SYK SYN1 TGM1 TH TOR1A TPPP TUBA1A UBB UBC USP2 USP47 USP7 USP8 YOD1 YWHAB YWHAE YWHAH ZRANB1	79 interacting genes: ACD ACTB ACTC1 ANXA1 ANXA7 APP AR ARL15 ATN1 ATXN1 BID BPGM BTBD2 CAMK1 CAMK2B CAMK4 CDKN1A CDKN2A CHP1 DYNLL1 EGFR FBXO7 FKBP6 GADD45A GAS7 GOT2 GRIA2 GRM1 HES1 HNF4G HSPB2 HTT KARS1 KAT5 KCNE3 LAMA4 LAMTOR5 LIG4 MAPK1 MTNR1A MYOC NFYC NR1H4 OSMR OSTF1 PAFAH1B3 PCDHA4 PCNA PDIA2 PGK1 PLD2 POT1 POU2F2 PPM1E PRDX1 PRKCI PRPF40A PSEN1 PSMD11 PTPRF RAB2A RBM5 RPA2 S100A6 SERPINB9 SIAH1 SIRT1 SLC2A1 SLC2A4 SMN1 SNCA SUMO4 TERF1 TINF2 TK1 TPPP USP25 YWHAE YWHAQ
Entrez ID		6622	2597
HPRD ID		01227	00713
Ensembl ID		ENSG00000145335	ENSG00000111640
Uniprot IDs		H6UYS5 P37840	P04406 V9HVZ4
PDB IDs		1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB	1U8F 1ZNQ 2FEH 3GPD 4WNC 4WNI 6ADE 6IQ6
Enriched GO Terms of Interacting Partners?
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