Wiki-CORONA
About
Search
Browse
Data Sources
People
Funding
Advanced Search
SNCA and MEF2D
Number of citations of the paper that reports this interaction (PubMedID
18541383
)
10
Data Source:
BioGRID
(pull down)
SNCA
MEF2D
Description
synuclein alpha
myocyte enhancer factor 2D
Image
No pdb structure
GO Annotations
Cellular Component
Extracellular Region
Extracellular Space
Cell
Nucleus
Cytoplasm
Mitochondrion
Lysosome
Cytosol
Plasma Membrane
Cell Cortex
Actin Cytoskeleton
Membrane
Inclusion Body
Cell Junction
Axon
Growth Cone
Platelet Alpha Granule Membrane
Protein-containing Complex
Perinuclear Region Of Cytoplasm
Presynapse
Supramolecular Fiber
Nuclear Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Intracellular Membrane-bounded Organelle
Molecular Function
SNARE Binding
Magnesium Ion Binding
Actin Binding
Fatty Acid Binding
Copper Ion Binding
Calcium Ion Binding
Protein Binding
Phospholipid Binding
Ferrous Iron Binding
Zinc Ion Binding
Oxidoreductase Activity
Kinesin Binding
Hsp70 Protein Binding
Histone Binding
Identical Protein Binding
Alpha-tubulin Binding
Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process
Transcription Regulatory Region DNA Binding
Tau Protein Binding
Phosphoprotein Binding
Phospholipase D Inhibitor Activity
Dynein Complex Binding
Cuprous Ion Binding
Transcription Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Activator Activity, RNA Polymerase II-specific
DNA-binding Transcription Factor Activity
Protein Binding
Transcription Factor Binding
Activating Transcription Factor Binding
Protein Homodimerization Activity
Histone Deacetylase Binding
Sequence-specific DNA Binding
Transcription Regulatory Region DNA Binding
Protein Heterodimerization Activity
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Microglial Cell Activation
Positive Regulation Of Receptor Recycling
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Response To Iron(II) Ion
Regulation Of Phospholipase Activity
Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway
Regulation Of Dopamine Secretion
Synaptic Vesicle Exocytosis
Synaptic Vesicle Priming
Regulation Of Transmembrane Transporter Activity
Negative Regulation Of Microtubule Polymerization
Receptor Internalization
Protein Destabilization
Response To Magnesium Ion
Negative Regulation Of Transporter Activity
Response To Lipopolysaccharide
Negative Regulation Of Monooxygenase Activity
Positive Regulation Of Peptidyl-serine Phosphorylation
Response To Interferon-gamma
Cellular Response To Oxidative Stress
Negative Regulation Of Histone Acetylation
SNARE Complex Assembly
Positive Regulation Of SNARE Complex Assembly
Dopamine Biosynthetic Process
Positive Regulation Of Apoptotic Process
Negative Regulation Of Apoptotic Process
Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Protein Metabolic Process
Positive Regulation Of Endocytosis
Negative Regulation Of Exocytosis
Positive Regulation Of Exocytosis
Synaptic Vesicle Endocytosis
Positive Regulation Of Inflammatory Response
Protein Tetramerization
Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol
Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission
Negative Regulation Of Serotonin Uptake
Regulation Of Norepinephrine Uptake
Negative Regulation Of Norepinephrine Uptake
Calcium Ion Homeostasis
Oxidation-reduction Process
Positive Regulation Of Inositol Phosphate Biosynthetic Process
Negative Regulation Of Thrombin-activated Receptor Signaling Pathway
Response To Interleukin-1
Cellular Response To Copper Ion
Cellular Response To Epinephrine Stimulus
Positive Regulation Of Protein Serine/threonine Kinase Activity
Supramolecular Fiber Organization
Negative Regulation Of Neuron Death
Positive Regulation Of Neuron Death
Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone
Positive Regulation Of Glutathione Peroxidase Activity
Positive Regulation Of Hydrogen Peroxide Catabolic Process
Regulation Of Synaptic Vesicle Recycling
Regulation Of Reactive Oxygen Species Biosynthetic Process
Negative Regulation Of Chaperone-mediated Autophagy
Regulation Of Presynapse Assembly
Osteoblast Differentiation
Endochondral Ossification
Chondrocyte Differentiation
Apoptotic Process
Multicellular Organism Development
Nervous System Development
Adult Heart Development
Muscle Organ Development
Skeletal Muscle Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of Vascular Smooth Muscle Cell Proliferation
Pathways
Amyloid fiber formation
Transcriptional activation of mitochondrial biogenesis
Circadian Clock
Myogenesis
NGF-stimulated transcription
NGF-stimulated transcription
Drugs
Resveratrol
Copper
Diseases
Lewy body dementia (LBD); Dementia with Lewy bodies (DLB)
Parkinson's disease (PD)
GWAS
Blood protein levels (
30072576
29875488
)
Dementia with Lewy bodies (
29263008
)
Emphysema annual change measurement in smokers (adjusted lung density) (
31324189
)
Feeling nervous (
29500382
)
Neurociticism (
29500382
)
Parkinson's disease (
22451204
20711177
21084426
21292315
19915575
19915576
25064009
31660654
27182965
28892059
22438815
28011712
20070850
21044948
24511991
21738487
)
Parkinson's disease (age of onset) (
31660654
30957308
)
Parkinson's disease in GBA mutation carriers (
31755958
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Response to bupropion in depression (
27622933
)
Headache (
29397368
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
22683712
27182965
23793025
27322543
)
Migraine - clinic-based (
23793025
)
Platelet count (
27863252
)
Plateletcrit (
27863252
)
Interacting Genes
123 interacting genes:
A1BG
ACTA1
ADAP2
AKT1
AMBRA1
ANXA6
APLP1
APP
ARHGAP15
ARPP19
BAD
BAG5
BCL2L1
BDH2
CALM1
CAV1
CDC42EP2
CDC42EP3
CDC42SE1
CDK4
COL25A1
CRYAB
CSNK1A1
CSNK1D
CSNK2A1
CSNK2A2
CTNND1
CTSD
CYCS
DMTN
DNAJC5
DOCK7
DYRK1A
EEF1A1
EGFR
EIF3G
ELK1
ENC1
ENSA
FBXL5
FGR
FKBP4
FYN
GABARAPL1
GAPDH
GBA
GRK1
GRK2
GRK5
GRK6
GSK3B
H1-1
H1-2
HSD17B4
HSP90AA1
HSPA1A
HSPA8
HSPB1
HSPB2
HSPB6
HSPB8
IARS1
KIAA1191
KLC1
KLK6
LYN
MAP1B
MAPK1
MAPK8IP1
MAPT
MEF2D
MT-CO1
MT-CO3
NEDD4
NEDD4L
PAK3
PDE4DIP
PDIA2
PELP1
PFDN2
PLCB2
PLD1
PLK1
PLK2
PLK3
PRDX1
PREP
PRKCE
PRKN
PTK2B
RABAC1
RNF10
SAP30BP
SDF4
SEPTIN4
SIAH2
SLC6A3
SMURF2
SNCAIP
SNCB
SPTBN1
SQSTM1
SRC
SRI
STAMBP
SYK
SYN1
TGM1
TH
TOR1A
TPPP
TUBA1A
UBB
UBC
USP2
USP47
USP7
USP8
YOD1
YWHAB
YWHAE
YWHAH
ZRANB1
23 interacting genes:
APP
ASCL1
CABIN1
CARM1
CASP7
CDK6
COPS5
DNMT3L
EP300
FBXO7
HDAC4
HDAC5
MAPK14
MAPK7
MEF2A
MEF2C
NFATC2
PRKACA
PRMT5
SKP2
SNCA
SP1
YWHAQ
Entrez ID
6622
4209
HPRD ID
01227
02810
Ensembl ID
ENSG00000145335
ENSG00000116604
Uniprot IDs
H6UYS5
P37840
Q14814
PDB IDs
1XQ8
2JN5
2KKW
2M55
2N0A
2X6M
3Q25
3Q26
3Q27
3Q28
3Q29
4BXL
4R0U
4R0W
4RIK
4RIL
4ZNN
5CRW
6A6B
6CT7
6CU7
6CU8
6FLT
6H6B
6OSJ
6OSL
6OSM
6PEO
6PES
6RT0
6RTB
Enriched GO Terms of Interacting Partners
?
Tagcloud
?
Tagcloud (Difference)
?
Tagcloud (Intersection)
?