SNCA and HSP90AA1

Number of citations of the paper that reports this interaction (PubMedID 19759002)
29

Data Source:
BioGRID (pull down)

		SNCA	HSP90AA1
Description		synuclein alpha	heat shock protein 90 alpha family class A member 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cell Nucleus Cytoplasm Mitochondrion Lysosome Cytosol Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Inclusion Body Cell Junction Axon Growth Cone Platelet Alpha Granule Membrane Protein-containing Complex Perinuclear Region Of Cytoplasm Presynapse Supramolecular Fiber	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Cell Surface Membrane Protein-containing Complex Secretory Granule Lumen Melanosome Neuronal Cell Body Lysosomal Lumen Myelin Sheath Dendritic Growth Cone Axonal Growth Cone Perinuclear Region Of Cytoplasm Extracellular Exosome Endocytic Vesicle Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	SNARE Binding Magnesium Ion Binding Actin Binding Fatty Acid Binding Copper Ion Binding Calcium Ion Binding Protein Binding Phospholipid Binding Ferrous Iron Binding Zinc Ion Binding Oxidoreductase Activity Kinesin Binding Hsp70 Protein Binding Histone Binding Identical Protein Binding Alpha-tubulin Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Transcription Regulatory Region DNA Binding Tau Protein Binding Phosphoprotein Binding Phospholipase D Inhibitor Activity Dynein Complex Binding Cuprous Ion Binding	RNA Binding Protein Binding ATP Binding ATPase Activity MHC Class II Protein Complex Binding Nitric-oxide Synthase Regulator Activity TPR Domain Binding Ubiquitin Protein Ligase Binding ATPase Activity, Coupled Identical Protein Binding Protein Homodimerization Activity Histone Deacetylase Binding Tau Protein Binding GTPase Binding Unfolded Protein Binding DNA Polymerase Binding Scaffold Protein Binding Disordered Domain Specific Binding Protein Tyrosine Kinase Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Microglial Cell Activation Positive Regulation Of Receptor Recycling Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Iron(II) Ion Regulation Of Phospholipase Activity Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Dopamine Secretion Synaptic Vesicle Exocytosis Synaptic Vesicle Priming Regulation Of Transmembrane Transporter Activity Negative Regulation Of Microtubule Polymerization Receptor Internalization Protein Destabilization Response To Magnesium Ion Negative Regulation Of Transporter Activity Response To Lipopolysaccharide Negative Regulation Of Monooxygenase Activity Positive Regulation Of Peptidyl-serine Phosphorylation Response To Interferon-gamma Cellular Response To Oxidative Stress Negative Regulation Of Histone Acetylation SNARE Complex Assembly Positive Regulation Of SNARE Complex Assembly Dopamine Biosynthetic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cellular Protein Metabolic Process Positive Regulation Of Endocytosis Negative Regulation Of Exocytosis Positive Regulation Of Exocytosis Synaptic Vesicle Endocytosis Positive Regulation Of Inflammatory Response Protein Tetramerization Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Negative Regulation Of Serotonin Uptake Regulation Of Norepinephrine Uptake Negative Regulation Of Norepinephrine Uptake Calcium Ion Homeostasis Oxidation-reduction Process Positive Regulation Of Inositol Phosphate Biosynthetic Process Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Response To Interleukin-1 Cellular Response To Copper Ion Cellular Response To Epinephrine Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Supramolecular Fiber Organization Negative Regulation Of Neuron Death Positive Regulation Of Neuron Death Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Glutathione Peroxidase Activity Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of Synaptic Vesicle Recycling Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Chaperone-mediated Autophagy Regulation Of Presynapse Assembly	G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Protein Phosphorylation Protein Folding Mitochondrial Transport Receptor-mediated Endocytosis Response To Unfolded Protein Telomere Maintenance Via Telomerase Response To Heat Response To Cold Regulation Of G2/M Transition Of Mitotic Cell Cycle Viral Process Cytokine-mediated Signaling Pathway Central Nervous System Neuron Axonogenesis Establishment Of Cell Polarity Regulation Of Protein Ubiquitination Positive Regulation Of Protein Polymerization Positive Regulation Of Peptidyl-serine Phosphorylation Cellular Response To Heat Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB2 Signaling Pathway Protein Refolding Regulation Of Protein Complex Assembly Neutrophil Degranulation Protein Unfolding Protein Import Into Mitochondrial Outer Membrane Positive Regulation Of Nitric Oxide Biosynthetic Process Response To Antibiotic Vascular Endothelial Growth Factor Receptor Signaling Pathway Axon Extension Protein Stabilization Regulation Of Nitric-oxide Synthase Activity Chaperone-mediated Protein Complex Assembly Cofactor Metabolic Process Positive Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Chaperone-mediated Autophagy Ciliary Basal Body-plasma Membrane Docking Regulation Of Cellular Response To Heat Positive Regulation Of Tau-protein Kinase Activity Positive Regulation Of Cellular Protein Catabolic Process Regulation Of Cellular Protein Localization Telomerase Holoenzyme Complex Assembly
Pathways		Amyloid fiber formation	Signaling by ERBB2 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation vRNP Assembly Regulation of actin dynamics for phagocytic cup formation eNOS activation Regulation of PLK1 Activity at G2/M Transition Scavenging by Class F Receptors Scavenging by Class F Receptors HSP90 chaperone cycle for steroid hormone receptors (SHR) HSF1 activation Attenuation phase HSF1-dependent transactivation Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Sema3A PAK dependent Axon repulsion VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway VEGFR2 mediated vascular permeability Uptake and function of diphtheria toxin PIWI-interacting RNA (piRNA) biogenesis Anchoring of the basal body to the plasma membrane Constitutive Signaling by EGFRvIII Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation The role of GTSE1 in G2/M progression after G2 checkpoint AURKA Activation by TPX2 Downregulation of ERBB2 signaling ESR-mediated signaling Extra-nuclear estrogen signaling Estrogen-dependent gene expression Chaperone Mediated Autophagy Constitutive Signaling by Overexpressed ERBB2 Aggrephagy Drug-mediated inhibition of ERBB2 signaling Signaling by ERBB2 KD Mutants Resistance of ERBB2 KD mutants to trastuzumab Resistance of ERBB2 KD mutants to sapitinib Resistance of ERBB2 KD mutants to tesevatinib Resistance of ERBB2 KD mutants to neratinib Resistance of ERBB2 KD mutants to osimertinib Resistance of ERBB2 KD mutants to afatinib Resistance of ERBB2 KD mutants to AEE788 Resistance of ERBB2 KD mutants to lapatinib Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants Drug resistance in ERBB2 TMD/JMD mutants
Drugs		Resveratrol Copper	Rifabutin Nedocromil 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-9h-Purin-6-Ylamine Geldanamycin 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-2-Fluoro-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine 9-Butyl-8-(3,4,5-Trimethoxybenzyl)-9h-Purin-6-Amine 4-(1,3-Benzodioxol-5-Yl)-5-(5-Ethyl-2,4-Dihydroxyphenyl)-2h-Pyrazole-3-Carboxylic Acid 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine 8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9-Pent-9h-Purin-6-Ylamine 9-Butyl-8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9h-Purin-6-Ylamine 4-(1h-Imidazol-4-Yl)-3-(5-Ethyl-2,4-Dihydroxy-Phenyl)-1h-Pyrazole 9-Butyl-8-(3-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(4-Methoxybenzyl)-9h-Purin-6-Amine 9-Butyl-8-(2,5-Dimethoxy-Benzyl)-2-Fluoro-9h-Purin-6-Ylamine Quercetin 8-Benzo[1,3]Dioxol-,5-Ylmethyl-9-Butyl-2-Fluoro-9h-Purin-6-Ylamine 8-(2-Chloro-3,4,5-Trimethoxy-Benzyl)-9-Pent-4-Ylnyl-9h-Purin-6-Ylamine N-[4-(AMINOSULFONYL)BENZYL]-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE Tanespimycin SNX-5422 N-(4-ACETYLPHENYL)-5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-1H-PYRAZOLE-4-CARBOXAMIDE 4-CHLORO-6-(4-{4-[4-(METHYLSULFONYL)BENZYL]PIPERAZIN-1-YL}-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-PIPERAZIN-1-YL-1H-PYRAZOLE-3-CARBOXAMIDE 5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-[4-(morpholin-4-ylmethyl)phenyl]isoxazole-3-carboxamide 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)ISOXAZOLE-3-CARBOXAMIDE 2-amino-4-[2,4-dichloro-5-(2-pyrrolidin-1-ylethoxy)phenyl]-N-ethylthieno[2,3-d]pyrimidine-6-carboxamide 4-CHLORO-6-(4-PIPERAZIN-1-YL-1H-PYRAZOL-5-YL)BENZENE-1,3-DIOL (3E)-3-[(phenylamino)methylidene]dihydrofuran-2(3H)-one 6-(3-BROMO-2-NAPHTHYL)-1,3,5-TRIAZINE-2,4-DIAMINE 3-({2-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)ETHYNYL]BENZYL}AMINO)-1,3-OXAZOL-2(3H)-ONE N-[(2-AMINO-6-METHYLPYRIMIDIN-4-YL)METHYL]-3-{[(E)-(2-OXODIHYDROFURAN-3(2H)-YLIDENE)METHYL]AMINO}BENZENESULFONAMIDE 5-(5-CHLORO-2,4-DIHYDROXYPHENYL)-N-ETHYL-4-(4-METHOXYPHENYL)-1H-PYRAZOLE-3-CARBOXAMIDE 4-bromo-6-(6-hydroxy-1,2-benzisoxazol-3-yl)benzene-1,3-diol 4-[4-(2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)-3-METHYL-1H-PYRAZOL-5-YL]-6-ETHYLBENZENE-1,3-DIOL 4-chloro-6-{5-[(2-morpholin-4-ylethyl)amino]-1,2-benzisoxazol-3-yl}benzene-1,3-diol 8-(6-BROMO-BENZO[1,3]DIOXOL-5-YLSULFANYL)-9-(3-ISOPROPYLAMINO-PROPYL)-ADENINE 4-methyl-7,8-dihydro-5H-thiopyrano[4,3-d]pyrimidin-2-amine (5E,7S)-2-amino-7-(4-fluoro-2-pyridin-3-ylphenyl)-4-methyl-7,8-dihydroquinazolin-5(6H)-one oxime 8-BENZO[1,3]DIOXOL-,5-YLMETHYL-9-BUTYL-9H- 4-{[(2R)-2-(2-methylphenyl)pyrrolidin-1-yl]carbonyl}benzene-1,3-diol 2-(1H-pyrrol-1-ylcarbonyl)benzene-1,3,5-triol 2-[(2-methoxyethyl)amino]-4-(4-oxo-1,2,3,4-tetrahydro-9H-carbazol-9-yl)benzamide 4-(2-methoxyethoxy)-6-methylpyrimidin-2-amine 4-(2,4-dichlorophenyl)-5-phenyldiazenyl-pyrimidin-2-amine 3,6-DIAMINO-5-CYANO-4-(4-ETHOXYPHENYL)THIENO[2,3-B]PYRIDINE-2-CARBOXAMIDE 2-AMINO-4-(2,4-DICHLOROPHENYL)-N-ETHYLTHIENO[2,3-D]PYRIMIDINE-6-CARBOXAMIDE Copper Alvespimycin
Diseases		Lewy body dementia (LBD); Dementia with Lewy bodies (DLB) Parkinson's disease (PD)
GWAS		Blood protein levels ( 30072576 29875488) Dementia with Lewy bodies ( 29263008) Emphysema annual change measurement in smokers (adjusted lung density) ( 31324189) Feeling nervous ( 29500382) Neurociticism ( 29500382) Parkinson's disease ( 22451204 20711177 21084426 21292315 19915575 19915576 25064009 31660654 27182965 28892059 22438815 28011712 20070850 21044948 24511991 21738487) Parkinson's disease (age of onset) ( 31660654 30957308) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Response to bupropion in depression ( 27622933)	Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143)
Interacting Genes		123 interacting genes: A1BG ACTA1 ADAP2 AKT1 AMBRA1 ANXA6 APLP1 APP ARHGAP15 ARPP19 BAD BAG5 BCL2L1 BDH2 CALM1 CAV1 CDC42EP2 CDC42EP3 CDC42SE1 CDK4 COL25A1 CRYAB CSNK1A1 CSNK1D CSNK2A1 CSNK2A2 CTNND1 CTSD CYCS DMTN DNAJC5 DOCK7 DYRK1A EEF1A1 EGFR EIF3G ELK1 ENC1 ENSA FBXL5 FGR FKBP4 FYN GABARAPL1 GAPDH GBA GRK1 GRK2 GRK5 GRK6 GSK3B H1-1 H1-2 HSD17B4 HSP90AA1 HSPA1A HSPA8 HSPB1 HSPB2 HSPB6 HSPB8 IARS1 KIAA1191 KLC1 KLK6 LYN MAP1B MAPK1 MAPK8IP1 MAPT MEF2D MT-CO1 MT-CO3 NEDD4 NEDD4L PAK3 PDE4DIP PDIA2 PELP1 PFDN2 PLCB2 PLD1 PLK1 PLK2 PLK3 PRDX1 PREP PRKCE PRKN PTK2B RABAC1 RNF10 SAP30BP SDF4 SEPTIN4 SIAH2 SLC6A3 SMURF2 SNCAIP SNCB SPTBN1 SQSTM1 SRC SRI STAMBP SYK SYN1 TGM1 TH TOR1A TPPP TUBA1A UBB UBC USP2 USP47 USP7 USP8 YOD1 YWHAB YWHAE YWHAH ZRANB1	153 interacting genes: AHR AHSA1 AHSA2P AIP AIPL1 AKT1 AKT2 APAF1 APOB AR ARNTL ASGR1 BIRC5 BRMS1 CACYBP CALM1 CDC37 CDC37L1 CDK4 CDK5R1 CDKN2A CERS2 CFTR CHEK1 CHUK CKS1B CKS2 CRNKL1 CSNK2A1 CSNK2A2 DAP3 DNAJC7 EGFR EGLN1 EIF2AK1 EIF2AK2 EIF2AK3 EIF2S1 EPAS1 EPRS1 ERBB2 ERN1 ESR1 ESRRB FAM162A FANCA FANCC FKBP1A FKBP4 FKBP5 FKBP6 FLCN FNIP1 FYN GNA12 GSK3B GUCY1B1 GZMA HDAC6 HIF1A HIF3A HSF1 HSPA8 HTT IKBKB IKBKE IKBKG IP6K2 IRAK1 IRF3 JUN KDR KEAP1 LCK LSM1 MAP3K14 MAP3K3 MAPK1 MAPT MIS12 MMP2 MS4A2 MTRNR2L1 MUC1 MYC MYOD1 NDRG1 NOS1 NOS3 NPAS2 NR2C2 NR3C1 NR3C2 NSL1 PABPN1 PAK1 PDPK1 PIM1 PMF1 PPARA PPARD PPID PPIL2 PPP5C PRKACA PRKCA PRKCD PRKDC PTGDS PTGES3 PTPRF RAD51 RAF1 RHOBTB2 RIPK1 RPAP3 RPS3 RPS3A RUNX1T1 SERPINB5 SGTA SIM1 SKP1 SLC2A4 SLC34A1 SMYD2 SMYD3 SNCA SRC ST13 STARD13 STAT3 STIP1 STUB1 SUGT1 SVIL TBK1 TERT TJP1 TNFRSF1A TOMM34 TOMM40 TOMM70 TP53 TTK TTR UBE2N UCHL1 UNC45A USP13 USP19 USP50 WASL
Entrez ID		6622	3320
HPRD ID		01227	00777
Ensembl ID		ENSG00000145335	ENSG00000080824
Uniprot IDs		H6UYS5 P37840	K9JA46 P07900 Q86SX1
PDB IDs		1XQ8 2JN5 2KKW 2M55 2N0A 2X6M 3Q25 3Q26 3Q27 3Q28 3Q29 4BXL 4R0U 4R0W 4RIK 4RIL 4ZNN 5CRW 6A6B 6CT7 6CU7 6CU8 6FLT 6H6B 6OSJ 6OSL 6OSM 6PEO 6PES 6RT0 6RTB	1BYQ 1OSF 1UY6 1UY7 1UY8 1UY9 1UYC 1UYD 1UYE 1UYF 1UYG 1UYH 1UYI 1UYK 1UYL 1YC1 1YC3 1YC4 1YER 1YES 1YET 2BSM 2BT0 2BUG 2BYH 2BYI 2BZ5 2C2L 2CCS 2CCT 2CCU 2FWY 2FWZ 2H55 2JJC 2K5B 2QF6 2QFO 2QG0 2QG2 2UWD 2VCI 2VCJ 2WI1 2WI2 2WI3 2WI4 2WI5 2WI6 2WI7 2XAB 2XDK 2XDL 2XDS 2XDU 2XDX 2XHR 2XHT 2XHX 2XJG 2XJJ 2XJX 2XK2 2YE2 2YE3 2YE4 2YE5 2YE6 2YE7 2YE8 2YE9 2YEA 2YEB 2YEC 2YED 2YEE 2YEF 2YEG 2YEH 2YEI 2YEJ 2YI0 2YI5 2YI6 2YI7 2YJW 2YJX 2YK2 2YK9 2YKB 2YKC 2YKE 2YKI 2YKJ 3B24 3B25 3B26 3B27 3B28 3BM9 3BMY 3D0B 3EKO 3EKR 3FT5 3FT8 3HEK 3HHU 3HYY 3HYZ 3HZ1 3HZ5 3INW 3INX 3K97 3K98 3K99 3MNR 3O0I 3OW6 3OWB 3OWD 3Q6M 3Q6N 3QDD 3QTF 3R4M 3R4N 3R4O 3R4P 3R91 3R92 3RKZ 3RLP 3RLQ 3RLR 3T0H 3T0Z 3T10 3T1K 3T2S 3TUH 3VHA 3VHC 3VHD 3WHA 3WQ9 4AIF 4AWO 4AWP 4AWQ 4B7P 4BQG 4BQJ 4CGQ 4CGU 4CGV 4CGW 4CWF 4CWN 4CWO 4CWP 4CWQ 4CWR 4CWS 4CWT 4EEH 4EFT 4EFU 4EGH 4EGI 4EGK 4FCP 4FCQ 4FCR 4HY6 4JQL 4L8Z 4L90 4L91 4L93 4L94 4LWE 4LWF 4LWG 4LWH 4LWI 4NH7 4NH8 4O04 4O05 4O07 4O09 4O0B 4R3M 4U93 4W7T 4XIP 4XIQ 4XIR 4XIT 4YKQ 4YKR 4YKT 4YKU 4YKW 4YKX 4YKY 4YKZ 5CF0 5FNC 5FND 5FNF 5GGZ 5J20 5J27 5J2V 5J2X 5J64 5J6L 5J6M 5J6N 5J80 5J82 5J86 5J8M 5J8U 5J9X 5LNY 5LNZ 5LO0 5LO1 5LO5 5LO6 5LQ9 5LR1 5LR7 5LRL 5LRZ 5LS1 5M4E 5M4H 5NYH 5NYI 5OCI 5OD7 5ODX 5T21 5VYY 5XQD 5XQE 5XR5 5XR9 5XRB 5XRD 5XRE 5ZR3 6B99 6B9A 6CEO 6CYG 6CYH 6EI5 6EL5 6ELN 6ELO 6ELP 6EY8 6EY9 6EYA 6EYB 6F1N 6FCJ 6FDP 6GP4 6GP8 6GPF 6GPH 6GPO 6GPP 6GPR 6GPT 6GPW 6GPY 6GQ6 6GQR 6GQS 6GQU 6GR1 6GR3 6GR4 6GR5 6HHR 6N8X 6OLX
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?