SHB and LAT

Number of citations of the paper that reports this interaction (PubMedID 12084069)
8

Data Source:
HPRD (in vivo)

		SHB	LAT
Description		SH2 domain containing adaptor protein B	linker for activation of T cells
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Cytoplasmic Ribonucleoprotein Granule	Immunological Synapse Golgi Apparatus Plasma Membrane Cell-cell Junction COP9 Signalosome Integral Component Of Membrane Mast Cell Granule Membrane Raft
	Molecular Function	Phosphotyrosine Residue Binding SH3/SH2 Adaptor Activity Protein Binding	SH3/SH2 Adaptor Activity Protein Binding Protein Kinase Binding
	Biological Process	Angiogenesis Apoptotic Process Signal Transduction Positive Regulation Of Signal Transduction Cell Differentiation Vascular Endothelial Growth Factor Receptor Signaling Pathway	MAPK Cascade Adaptive Immune Response Lymphocyte Homeostasis Inflammatory Response Immune Response Integrin-mediated Signaling Pathway Ras Protein Signal Transduction Positive Regulation Of Signal Transduction Gene Expression Calcium-mediated Signaling Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway T Cell Activation Mast Cell Degranulation Positive Regulation Of Protein Kinase Activity T Cell Receptor Signaling Pathway Regulation Of T Cell Activation
Pathways		VEGFA-VEGFR2 Pathway VEGFA-VEGFR2 Pathway	GPVI-mediated activation cascade Generation of second messenger molecules
Drugs
Diseases
GWAS		Brain structure ( 20171287) Chronotype ( 30696823) Loneliness (linear analysis) ( 27629369) Metabolite levels (Dihydroxy docosatrienoic acid) ( 23934736) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878) Type 2 diabetes (age of onset) ( 28060188)	Allergic disease (asthma, hay fever or eczema) ( 29679657) Crohn's disease ( 21102463) Educational attainment ( 25201988)
Interacting Genes		19 interacting genes: ABL1 CRK EPS8 GRAP2 GRB2 IL2RB IL2RG JAK1 JAK3 KDR LAT LCP2 PDGFRA PIK3R1 PLCG1 SLC39A1 SRC VAV1 ZAP70	33 interacting genes: CBL CD244 CD4 CD8A CREB3 EGFR FCGR1A FCGR2A FYN GAB2 GRAP GRAP2 GRB2 ITK KASH5 LCK LCP2 LMNA MAP4K1 PIK3R1 PLCG1 PLCG2 PTPN1 PTPN6 PTPRJ SGTA SH3BP2 SHB SLA SYK VAV1 ZAP70 ZHX2
Entrez ID		6461	27040
HPRD ID		02635	03832
Ensembl ID		ENSG00000107338	ENSG00000213658
Uniprot IDs		Q15464	A0A024QZD6 O43561
PDB IDs
Enriched GO Terms of Interacting Partners?
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