SH3GL1 and MAL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SH3GL1	MAL2
Description		SH3 domain containing GRB2 like 1, endophilin A2	mal, T cell differentiation protein 2 (gene/pseudogene)
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Podosome Cytoplasm Cytosol Cell Junction Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Endomembrane System Integral Component Of Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Ion Channel Binding Cadherin Binding GTPase Binding	Protein Binding Structural Constituent Of Myelin Sheath
	Biological Process	Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis	Myelination Transcytosis
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS			Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)
Interacting Genes		27 interacting genes: ARHGAP8 AXIN1 B3GAT1 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 LRRK2 MAL2 MTA1 PDCD6IP PML PTPRO SEPTIN8 SH2D4A SH3D19 SH3GL3 SYNJ1 VIM VPS37C YWHAZ	21 interacting genes: ABCG8 ARFIP2 CREB3 FAM3A GAD1 GAD2 NDRG4 PBX3 PIMREG PPP1CA PTPN9 RAB37 S100B SH3GL1 SHMT2 TBRG4 TPD52 TPD52L1 TPD52L2 TUBB VARS2
Entrez ID		6455	114569
HPRD ID		03462	14351
Ensembl ID		ENSG00000141985	ENSG00000147676
Uniprot IDs		Q6FGM0 Q99961	A0A024R9E4 Q969L2
PDB IDs
Enriched GO Terms of Interacting Partners?
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