MAL2 and SH3GL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MAL2	SH3GL1
Description		mal, T cell differentiation protein 2 (gene/pseudogene)	SH3 domain containing GRB2 like 1, endophilin A2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Apical Plasma Membrane Membrane Raft Perinuclear Region Of Cytoplasm Extracellular Exosome	Podosome Cytoplasm Cytosol Cell Junction Early Endosome Membrane Cell Projection Schaffer Collateral - CA1 Synapse Hippocampal Mossy Fiber To CA3 Synapse Presynapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding Structural Constituent Of Myelin Sheath	Protein Binding Protein C-terminus Binding Lipid Binding SH3 Domain Binding Phosphatase Binding Beta-1 Adrenergic Receptor Binding Identical Protein Binding Ion Channel Binding Cadherin Binding GTPase Binding
	Biological Process	Myelination Transcytosis	Signal Transduction Central Nervous System Development Synaptic Vesicle Uncoating Modulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Vesicle Endocytosis
Pathways			EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell
Drugs
Diseases
GWAS		Blood pressure (smoking interaction) ( 25189868) Gallstone disease ( 30504769) Hippocampal atrophy ( 19668339) Osteoprotegerin levels ( 25080503)
Interacting Genes		21 interacting genes: ABCG8 ARFIP2 CREB3 FAM3A GAD1 GAD2 NDRG4 PBX3 PIMREG PPP1CA PTPN9 RAB37 S100B SH3GL1 SHMT2 TBRG4 TPD52 TPD52L1 TPD52L2 TUBB VARS2	27 interacting genes: ARHGAP8 AXIN1 B3GAT1 CREBBP DNM1 DNM1L DPPA4 DPYSL4 FAM102A FBXO32 GPKOW ITCH ITSN2 LRRK2 MAL2 MTA1 PDCD6IP PML PTPRO SEPTIN8 SH2D4A SH3D19 SH3GL3 SYNJ1 VIM VPS37C YWHAZ
Entrez ID		114569	6455
HPRD ID		14351	03462
Ensembl ID		ENSG00000147676	ENSG00000141985
Uniprot IDs		A0A024R9E4 Q969L2	Q6FGM0 Q99961
PDB IDs
Enriched GO Terms of Interacting Partners?
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