SRSF1 and NFYA

Number of citations of the paper that reports this interaction (PubMedID 15243141)
14

Data Source:
HPRD (in vivo, in vitro)

		SRSF1	NFYA
Description		serine and arginine rich splicing factor 1	nuclear transcription factor Y subunit alpha
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs		Copper
Diseases
GWAS			White blood cell count ( 27863252)
Interacting Genes		40 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	42 interacting genes: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NEU1 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 USF1 USF2 ZC3H10 ZHX1 ZHX2 ZHX3
Entrez ID		6426	4800
HPRD ID		02887	01793
Ensembl ID		ENSG00000136450	ENSG00000001167
Uniprot IDs		Q07955 Q59FA2	A0A024RD22 P23511
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O	4AWL 6QMP
Enriched GO Terms of Interacting Partners?
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