NFYA and PAPOLG

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		NFYA	PAPOLG
Description		nuclear transcription factor Y subunit alpha	poly(A) polymerase gamma
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex	Nucleus Nucleoplasm Cytosol Membrane Nuclear Body
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	RNA Binding Polynucleotide Adenylyltransferase Activity ATP Binding Metal Ion Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process	MRNA Polyadenylation RNA Polyadenylation
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		White blood cell count ( 27863252)	Acne (severe) ( 24927181) Composite immunoglobulin trait (IgA/IgM) ( 28628107) Crohn's disease ( 22412388) Erectile dysfunction ( 30583798) Metabolite levels ( 23823483) Multiple sclerosis ( 31604244) Systemic lupus erythematosus ( 28714469)
Interacting Genes		42 interacting genes: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NEU1 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 USF1 USF2 ZC3H10 ZHX1 ZHX2 ZHX3	3 interacting genes: LZTR1 NFYA PCBD1
Entrez ID		4800	64895
HPRD ID		01793	11420
Ensembl ID		ENSG00000001167	ENSG00000115421
Uniprot IDs		A0A024RD22 P23511	Q9BWT3
PDB IDs		4AWL 6QMP	4LT6
Enriched GO Terms of Interacting Partners?
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