NFYA and PWP1

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		NFYA	PWP1
Description		nuclear transcription factor Y subunit alpha	PWP1 homolog, endonuclein
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm CCAAT-binding Factor Complex Protein-DNA Complex RNA Polymerase II Transcription Factor Complex	Nucleus Chromosome Nucleolus Golgi Apparatus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Transcription Regulatory Region DNA Binding	H4K20me3 Modified Histone Binding
	Biological Process	Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Iron Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Rhythmic Process	Transcription, DNA-templated Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Histone H4-K20 Trimethylation Ribosome Biogenesis Positive Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Positive Regulation Of Stem Cell Differentiation
Pathways		PPARA activates gene expression Activation of gene expression by SREBF (SREBP) Activation of gene expression by SREBF (SREBP) ATF4 activates genes in response to endoplasmic reticulum stress ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes FOXO-mediated transcription of cell death genes
Drugs
Diseases
GWAS		White blood cell count ( 27863252)	Acne (severe) ( 24927181)
Interacting Genes		42 interacting genes: APP APPBP2 ATF6 ATF6B BRCA1 CCNA2 CDC25A CDK2 CDKN1A CEBPA CSNK2A1 E2F6 ELF1 GTF2A1 HMGA1 JUN KPNB1 LUC7L2 NEU1 NFYB NFYC NR5A1 PAPOLG POGZ POU2F1 PWP1 SP1 SPI1 SREBF2 SRF SRSF1 TAF11 TAF12 TAF6 TCAF1 TP53 USF1 USF2 ZC3H10 ZHX1 ZHX2 ZHX3	5 interacting genes: APP DAPK1 HOXA3 NFYA SMURF1
Entrez ID		4800	11137
HPRD ID		01793	11464
Ensembl ID		ENSG00000001167	ENSG00000136045
Uniprot IDs		A0A024RD22 P23511	A0A024RBH5 B4DJV5 Q13610
PDB IDs		4AWL 6QMP
Enriched GO Terms of Interacting Partners?
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