SRSF1 and U2AF1

Number of citations of the paper that reports this interaction (PubMedID 8261509)
329

Data Source:
BioGRID (pull down, two hybrid, biochemical, two hybrid)
HPRD (in vivo, in vitro)

		SRSF1	U2AF1
Description		serine and arginine rich splicing factor 1	U2 small nuclear RNA auxiliary factor 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Speck Exon-exon Junction Complex Catalytic Step 2 Spliceosome	Nucleoplasm Spliceosomal Complex Cajal Body Nuclear Speck Catalytic Step 2 Spliceosome U2AF
	Molecular Function	RNA Binding MRNA Binding Protein Binding DNA Topoisomerase Binding	RNA Binding Protein Binding Pre-mRNA 3'-splice Site Binding Metal Ion Binding
	Biological Process	Alternative MRNA Splicing, Via Spliceosome Regulation Of Alternative MRNA Splicing, Via Spliceosome MRNA 5'-splice Site Recognition MRNA Splicing, Via Spliceosome MRNA Splice Site Selection MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus MRNA 3'-end Processing MRNA Cis Splicing, Via Spliceosome	MRNA Splicing, Via Spliceosome MRNA Processing RNA Export From Nucleus MRNA Export From Nucleus RNA Splicing MRNA 3'-end Processing
Pathways		Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination	Transport of Mature mRNA derived from an Intron-Containing Transcript mRNA Splicing - Major Pathway mRNA 3'-end processing RNA Polymerase II Transcription Termination
Drugs		Copper
Diseases
GWAS			Blood and toenail selenium levels ( 25343990)
Interacting Genes		40 interacting genes: AKAP17A APP BCL10 C1QBP CACNA1A CD8A CDK12 CDK6 CLK1 DIDO1 DYRK1A GEMIN2 HIPK3 HNRNPA0 LNX1 LUC7L3 NFYA NXF1 PRPF4 PRPF4B PSIP1 RNPS1 SCAF11 SNRNP70 SREK1 SRPK1 SRPK2 SRSF10 SRSF11 SRSF4 SRSF5 TCERG1 TNPO3 TOP1 TP53 U2AF1 U2AF2 XBP1 YTHDC1 ZRSR2	38 interacting genes: AP2B1 CHERP CIR1 CLK2 DHX38 EPB41 FRA10AC1 HINFP HNRNPK HNRNPM IL7R JMJD6 MAP1B MFAP1 NDN NKAP NXF1 PABPC1 PRPF19 PRPF38A PRPF4 PRPF40A RBM10 RNPS1 RP9 SF3A3 SF3B2 SNRPD1 SRPK1 SRSF1 SRSF2 SUV39H1 TOE1 U2AF2 VEGFA ZCCHC10 ZRANB2 ZRSR2
Entrez ID		6426	7307
HPRD ID		02887	01871
Ensembl ID		ENSG00000136450	ENSG00000160201
Uniprot IDs		Q07955 Q59FA2	P0DN76 Q01081 Q7Z780
PDB IDs		1X4A 2M7S 2M8D 2O3D 3BEG 4C0O	1JMT
Enriched GO Terms of Interacting Partners?
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