ABCG8 and LMNB1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ABCG8	LMNB1
Description		ATP binding cassette subfamily G member 8	lamin B1
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane ATP-binding Cassette (ABC) Transporter Complex Receptor Complex	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Matrix Nuclear Membrane
	Molecular Function	Protein Binding ATP Binding ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Metal Ion Binding Protein Heterodimerization Activity Intermembrane Cholesterol Transfer Activity	Structural Molecule Activity Protein Binding Phospholipase Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Response To Nutrient Excretion Negative Regulation Of Intestinal Phytosterol Absorption Phospholipid Transport Sterol Transport Intestinal Cholesterol Absorption Cholesterol Efflux Response To Drug Cholesterol Homeostasis Negative Regulation Of Intestinal Cholesterol Absorption Transmembrane Transport	Interleukin-12-mediated Signaling Pathway
Pathways		ABC transporters in lipid homeostasis Defective ABCG8 causes gallbladder disease 4 and sitosterolemia Defective ABCG5 causes sitosterolemia NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs
Diseases		Sitosterolemia
GWAS		C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 28270201 25961943 20686565) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Gallstone disease ( 30325047 30504769 30692554 27094239 17632509) LDL cholesterol ( 23726366 19060906 30275531 25961943 20686565) LDL cholesterol levels ( 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) LDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Lipid metabolism phenotypes ( 19936222) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Phytosterol levels ( 20529992) Total cholesterol levels ( 30275531)	Blood protein levels ( 30072576 29875488) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)
Interacting Genes		8 interacting genes: ABCG5 AGPAT2 AKT2 ANG LMNB1 MAL2 NR4A1 NUPR1	29 interacting genes: ABCG8 ATF4 CASP3 CASP6 CDK1 GABARAP GIT2 GZMA GZMB LBR LMNA MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PLEC PRKCA PRKCB PRKCD PRPH RNF123 SERPINA3 SRPK2 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ
Entrez ID		64241	4001
HPRD ID		05679	01036
Ensembl ID		ENSG00000143921	ENSG00000113368
Uniprot IDs		Q9H221	B4DZT3 P20700
PDB IDs		5DO7	2KPW 3JT0 3TYY 3UMN 5VVX
Enriched GO Terms of Interacting Partners?
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