LMNB1 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LMNB1	SERPINA3
Description		lamin B1	serpin family A member 3
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Lamin Filament Nucleoplasm Membrane Nuclear Matrix Nuclear Membrane	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Structural Molecule Activity Protein Binding Phospholipase Binding Sequence-specific Double-stranded DNA Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Interleukin-12-mediated Signaling Pathway	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation
Pathways		Meiotic synapsis Formation of Senescence-Associated Heterochromatin Foci (SAHF) Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Breakdown of the nuclear lamina Depolymerisation of the Nuclear Lamina Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation	Platelet degranulation Neutrophil degranulation
Drugs			Zinc
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body fat percentage ( 31752434) Parkinson's disease (motor and cognition) ( 22658654)	Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)
Interacting Genes		29 interacting genes: ABCG8 ATF4 CASP3 CASP6 CDK1 GABARAP GIT2 GZMA GZMB LBR LMNA MAP1LC3A MAP1LC3C MBIP MELK PIAS2 PLEC PRKCA PRKCB PRKCD PRPH RNF123 SERPINA3 SRPK2 SUMO4 TMPO TOR1AIP1 URB2 YWHAQ	26 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		4001	12
HPRD ID		01036	00120
Ensembl ID		ENSG00000113368	ENSG00000196136
Uniprot IDs		B4DZT3 P20700	A0A024R6P0 P01011
PDB IDs		2KPW 3JT0 3TYY 3UMN 5VVX	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE
Enriched GO Terms of Interacting Partners?
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