PRDM14 and ATPAF2

Number of citations of the paper that reports this interaction (PubMedID 25910212)
127

Data Source:
BioGRID (two hybrid)

		PRDM14	ATPAF2
Description		PR/SET domain 14	ATP synthase mitochondrial F1 complex assembly factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Mitochondrion Cytosol Nuclear Speck
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Germ Cell Development Embryo Implantation Fertilization Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance	Proton-transporting ATP Synthase Complex Assembly
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases			Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Schizophrenia ( 28991256 25056061 29483656)
Interacting Genes		32 interacting genes: AKAP9 ATPAF2 BAG4 BCAR3 BEX2 CASP8 CDCA7L CHEK2 DGCR6 EED EIF4E2 ERBB2 EZH2 GPATCH2L HEXIM2 HSPB7 ID3 IDH1 MIA3 NDUFB9 PALB2 PAX2 PLEKHF2 PRKAB2 PSMA1 PTPRJ RAD51D RBM10 RCOR3 SUZ12 TEKT4 TTC32	24 interacting genes: APP ATP5F1A ATP5F1B BEGAIN CFAP206 DDIT3 EBF1 EWSR1 IKZF3 KRT40 LNX1 LRRFIP2 LZTS2 MAGEA6 PAK5 PKP4 PRDM14 RAD54B REL RPIA SORBS2 TP53BP2 TRIM23 TRIM27
Entrez ID		63978	91647
HPRD ID		11457	10599
Ensembl ID		ENSG00000147596	ENSG00000171953
Uniprot IDs		Q9GZV8	Q8N5M1
PDB IDs
Enriched GO Terms of Interacting Partners?
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