PRDM14 and RCOR3

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		PRDM14	RCOR3
Description		PR/SET domain 14	REST corepressor 3
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Nucleus Transcriptional Repressor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Transcription Factor Binding Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Germ Cell Development Embryo Implantation Fertilization Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance	Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleic Acid-templated Transcription
Pathways		Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS		Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		32 interacting genes: AKAP9 ATPAF2 BAG4 BCAR3 BEX2 CASP8 CDCA7L CHEK2 DGCR6 EED EIF4E2 ERBB2 EZH2 GPATCH2L HEXIM2 HSPB7 ID3 IDH1 MIA3 NDUFB9 PALB2 PAX2 PLEKHF2 PRKAB2 PSMA1 PTPRJ RAD51D RBM10 RCOR3 SUZ12 TEKT4 TTC32	32 interacting genes: APP CCDC102B CDR2 CEP55 CEP70 GOLGA2 GSE1 IKZF3 KDM1A KRT15 KRT31 KRT40 LCA5 LUZP4 LZTS2 MAGEA6 MARK3 MID2 MIPOL1 NECAB2 NINL PHF21B PRDM14 SUMO2 TFIP11 TRAF2 TRIM27 TRIM42 TRIM54 TSGA10 TXLNA YWHAQ
Entrez ID		63978	55758
HPRD ID		11457	08338
Ensembl ID		ENSG00000147596	ENSG00000117625
Uniprot IDs		Q9GZV8	Q9P2K3
PDB IDs			4CZZ
Enriched GO Terms of Interacting Partners?
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