CCL25 and ACKR4

Number of citations of the paper that reports this interaction (PubMedID 10706668)
34

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		CCL25	ACKR4
Description		C-C motif chemokine ligand 25	atypical chemokine receptor 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cell Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome
	Molecular Function	Hormone Activity Protein Binding Chemokine Activity CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Monocyte Chemotaxis Chemotaxis Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Lymphocyte Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Negative Regulation Of Leukocyte Tethering Or Rolling	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Metabolite levels ( 23823483) Neurocognitive impairment in HIV-1 infection (continuous) ( 28447399) Sphingolipid levels ( 26068415)	Blood protein levels ( 28240269) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		4 interacting genes: ACKR2 ACKR4 CCR10 CCR9	11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6370	51554
HPRD ID		03976	07298
Ensembl ID		ENSG00000131142	ENSG00000129048
Uniprot IDs		O15444	Q9NPB9
PDB IDs
Enriched GO Terms of Interacting Partners?
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