ACKR4 and CCL19

Number of citations of the paper that reports this interaction (PubMedID 10706668)
34

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		ACKR4	CCL19
Description		atypical chemokine receptor 4	C-C motif chemokine ligand 19
Image		No pdb structure
GO Annotations	Cellular Component	Cell Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space Cell
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding	Chemokine Activity CCR7 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding Chemokine Receptor Binding CCR Chemokine Receptor Binding
	Biological Process	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Establishment Of T Cell Polarity Immunological Synapse Formation Dendritic Cell Chemotaxis Myeloid Dendritic Cell Chemotaxis Monocyte Chemotaxis Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Cellular Calcium Ion Homeostasis Inflammatory Response Immune Response Cell Communication G Protein-coupled Receptor Signaling Pathway Activation Of JUN Kinase Activity Response To Virus Positive Regulation Of Glycoprotein Biosynthetic Process Cytokine-mediated Signaling Pathway Neutrophil Chemotaxis T Cell Costimulation Positive Regulation Of Interleukin-12 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Prostaglandin E Positive Regulation Of T Cell Proliferation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Positive Regulation Of T-helper 1 Cell Differentiation Positive Regulation Of Endocytosis Positive Regulation Of Protein Kinase Activity Positive Regulation Of JNK Cascade Lymphocyte Chemotaxis Positive Regulation Of Receptor-mediated Endocytosis Cell Maturation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Chemotaxis Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Protein Kinase B Signaling Regulation Of Cell Projection Assembly Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Response To Nitric Oxide Interleukin-12 Secretion Positive Regulation Of Neutrophil Chemotaxis Mature Conventional Dendritic Cell Differentiation Cellular Response To Virus Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Cell Motility Positive Regulation Of Dendritic Cell Dendrite Assembly Negative Regulation Of Dendritic Cell Apoptotic Process
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)
Interacting Genes		11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	6 interacting genes: ACKR2 ACKR4 CCL22 CCR10 CCR7 CXCL13
Entrez ID		51554	6363
HPRD ID		07298	03750
Ensembl ID		ENSG00000129048	ENSG00000172724
Uniprot IDs		Q9NPB9	Q6IBD6 Q99731
PDB IDs			2MP1
Enriched GO Terms of Interacting Partners?
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