ACKR4 and CCL13

Number of citations of the paper that reports this interaction (PubMedID 10734104)
12

Data Source:
HPRD (in vitro)

		ACKR4	CCL13
Description		atypical chemokine receptor 4	C-C motif chemokine ligand 13
Image		No pdb structure
GO Annotations	Cellular Component	Cell Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space Cell
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding	Signaling Receptor Binding Protein Binding Chemokine Activity CCR Chemokine Receptor Binding
	Biological Process	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Killing Of Cells Of Other Organism Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Blood protein levels ( 29875488) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	9 interacting genes: ACKR2 ACKR4 APP CCR3 CCR5 HNRNPH3 MMP1 MMP3 NOD2
Entrez ID		51554	6357
HPRD ID		07298	03230
Ensembl ID		ENSG00000129048	ENSG00000181374
Uniprot IDs		Q9NPB9	Q99616
PDB IDs			2RA4
Enriched GO Terms of Interacting Partners?
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