ACKR4 and CCL11

Number of citations of the paper that reports this interaction (PubMedID 10734104)
12

Data Source:
HPRD (in vitro)

		ACKR4	CCL11
Description		atypical chemokine receptor 4	C-C motif chemokine ligand 11
Image		No pdb structure
GO Annotations	Cellular Component	Cell Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space Cell
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding	Protein Binding Chemokine Activity CCR3 Chemokine Receptor Binding Protein Dimerization Activity Receptor Ligand Activity CCR Chemokine Receptor Binding
	Biological Process	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Positive Regulation Of Endothelial Cell Proliferation Chronic Inflammatory Response Monocyte Chemotaxis Mast Cell Chemotaxis Protein Phosphorylation Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Actin Filament Organization Cell Adhesion Signal Transduction G Protein-coupled Receptor Signaling Pathway Learning Or Memory Regulation Of Cell Shape Response To Radiation Response To Virus Cytokine-mediated Signaling Pathway Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of Actin Filament Polymerization Response To Interleukin-13 Positive Regulation Of GTPase Activity Positive Regulation Of Angiogenesis Eosinophil Chemotaxis Lymphocyte Chemotaxis Negative Regulation Of Neurogenesis Branching Involved In Mammary Gland Duct Morphogenesis Mammary Duct Terminal End Bud Growth Chemokine-mediated Signaling Pathway ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Response To Interleukin-4 Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Modulation Of Age-related Behavioral Decline
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines Interleukin-4 and Interleukin-13 signaling
Drugs			CAT-213
Diseases
GWAS		Blood protein levels ( 28240269) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Crohn's disease ( 28067908 22412388) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908 23128233)
Interacting Genes		11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	7 interacting genes: ACKR2 ACKR4 CCR3 CCR5 DPP4 NUDT3 TPI1
Entrez ID		51554	6356
HPRD ID		07298	03098
Ensembl ID		ENSG00000129048	ENSG00000172156
Uniprot IDs		Q9NPB9	P51671 Q6I9T4
PDB IDs			1EOT 2EOT 2MPM
Enriched GO Terms of Interacting Partners?
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