ACKR4 and CXCL13

Number of citations of the paper that reports this interaction (PubMedID 10706668)
34

Data Source:
HPRD (in vitro)

		ACKR4	CXCL13
Description		atypical chemokine receptor 4	C-X-C motif chemokine ligand 13
Image		No pdb structure
GO Annotations	Cellular Component	Cell Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome	Extracellular Region Extracellular Space Cell
	Molecular Function	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding	Chemokine Activity Heparin Binding Fibroblast Growth Factor Binding CXCR5 Chemokine Receptor Binding CCR10 Chemokine Receptor Binding CXCR Chemokine Receptor Binding Receptor Ligand Activity CXCR3 Chemokine Receptor Binding
	Biological Process	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway	Germinal Center Formation Lymphocyte Chemotaxis Across High Endothelial Venule Chronic Inflammatory Response Regulation Of Humoral Immune Response Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Cell-cell Signaling Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Leukocyte Chemotaxis Positive Regulation Of Integrin Activation Positive Regulation Of Cell-cell Adhesion Mediated By Integrin B Cell Chemotaxis Endothelial Cell Chemotaxis To Fibroblast Growth Factor Defense Response To Bacterium Regulation Of Angiogenesis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Activation Of GTPase Activity Negative Regulation Of Endothelial Cell Chemotaxis To Fibroblast Growth Factor
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)	Cardiac Troponin-T levels ( 23247143) Diffusing capacity of carbon monoxide ( 30694715) Tonsillectomy ( 27182965 28928442) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13	8 interacting genes: ACKR4 CCL19 CCL21 CCR10 CXCR3 CXCR5 EEF1G FGF2
Entrez ID		51554	10563
HPRD ID		07298	05513
Ensembl ID		ENSG00000129048	ENSG00000156234
Uniprot IDs		Q9NPB9	O43927 Q53X90
PDB IDs			4ZAI 5CBA 5CBE
Enriched GO Terms of Interacting Partners?
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