CCL7 and ACKR4

Number of citations of the paper that reports this interaction (PubMedID 10734104)
12

Data Source:
HPRD (in vitro)

		CCL7	ACKR4
Description		C-C motif chemokine ligand 7	atypical chemokine receptor 4
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cell	Cell Early Endosome Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Recycling Endosome
	Molecular Function	Protein Binding Chemokine Activity Heparin Binding CCR1 Chemokine Receptor Binding CCR2 Chemokine Receptor Binding CCR Chemokine Receptor Binding	Chemokine Receptor Activity Scavenger Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding
	Biological Process	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Response To Gamma Radiation Positive Regulation Of Cell Migration Neutrophil Chemotaxis Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Ethanol Positive Regulation Of Natural Killer Cell Chemotaxis	Endocytosis Chemotaxis Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium-mediated Signaling Cell Chemotaxis Chemokine-mediated Signaling Pathway
Pathways		Chemokine receptors bind chemokines	Chemokine receptors bind chemokines
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Crohn's disease ( 28067908 22412388 21102463) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 28067908)	Blood protein levels ( 28240269) Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952)
Interacting Genes		16 interacting genes: AATF ACKR1 ACKR2 ACKR4 CCR1 CCR10 CCR3 CCR5 FEZ1 MMP1 MMP13 MMP14 MMP2 MMP3 TLE5 UBQLN1	11 interacting genes: CCL11 CCL13 CCL19 CCL2 CCL21 CCL25 CCL5 CCL7 CCL8 CDK2 CXCL13
Entrez ID		6354	51554
HPRD ID		01150	07298
Ensembl ID		ENSG00000108688	ENSG00000129048
Uniprot IDs		P80098	Q9NPB9
PDB IDs		1BO0 1NCV 4ZKC
Enriched GO Terms of Interacting Partners?
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