RPL6 and EIF6

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid, biochemical)
HPRD (two hybrid)

		RPL6	EIF6
Description		ribosomal protein L6	eukaryotic translation initiation factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Rough Endoplasmic Reticulum Cytosol Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome	Nucleus Lamin Filament Nucleoplasm Nucleolus Cytoplasm Cytosol Preribosome, Large Subunit Precursor Extracellular Exosome
	Molecular Function	DNA Binding RNA Binding Structural Constituent Of Ribosome Cadherin Binding	Translation Initiation Factor Activity Protein Binding Ribosome Binding Ribosomal Large Subunit Binding
	Biological Process	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Regulation Of Transcription, DNA-templated Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription	Ribosomal Subunit Export From Nucleus Maturation Of 5.8S RRNA Maturation Of LSU-rRNA Regulation Of Glycolytic Process Translational Initiation Response To Insulin Gene Silencing By MiRNA MiRNA Mediated Inhibition Of Translation Mature Ribosome Assembly Regulation Of Fatty Acid Biosynthetic Process Regulation Of Megakaryocyte Differentiation Positive Regulation Of Translation Assembly Of Large Subunit Precursor Of Preribosome Regulation Of Reactive Oxygen Species Metabolic Process
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
Drugs			Copper
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood pressure ( 21572416) Body mass index ( 26426971) Coffee consumption ( 29367735) Diastolic blood pressure ( 26390057) Esophageal cancer ( 21642993) Systolic blood pressure ( 26390057)	Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Height ( 18391951) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: CSNK2A1 EIF6 FBXO7 FGF2 H2AC4 IL7R IVNS1ABP MAP3K14 MT-ND1 NFKB2 NPAS2 RPL29 SEL1L STAU1	37 interacting genes: ABCF1 ACAP3 ACTG1 AKT1S1 ALDH2 APP CEP126 CLEC4G CRELD1 CSNK2B DHX58 EIF2AK2 ENOX1 FUNDC2 GIT1 HIP1 HPF1 ITGB4 LRIF1 MRPS31 OAS3 OFD1 OS9 PDHA1 PLK1 POLA2 PRKCB PSME1 RACK1 RPL6 SEPTIN3 TK1 UPF3B USP33 WFS1 XRN2 ZBTB26
Entrez ID		6128	3692
HPRD ID		04745	04221
Ensembl ID		ENSG00000089009	ENSG00000242372
Uniprot IDs		A0A024RBK3 Q02878 Q8TBK5	P56537
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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