RPL6 and NFKB2

Number of citations of the paper that reports this interaction (PubMedID 14743216)
300

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro)

		RPL6	NFKB2
Description		ribosomal protein L6	nuclear factor kappa B subunit 2
Image
GO Annotations	Cellular Component	Nucleus Rough Endoplasmic Reticulum Cytosol Focal Adhesion Postsynaptic Density Membrane Cytosolic Large Ribosomal Subunit Cytoplasmic Ribonucleoprotein Granule Polysomal Ribosome	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol I-kappaB/NF-kappaB Complex Bcl3/NF-kappaB2 Complex
	Molecular Function	DNA Binding RNA Binding Structural Constituent Of Ribosome Cadherin Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding
	Biological Process	Ribosomal Large Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Regulation Of Transcription, DNA-templated Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Viral Transcription	Negative Regulation Of Transcription By RNA Polymerase II Follicular Dendritic Cell Differentiation Germinal Center Formation Regulation Of Transcription, DNA-templated Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Aging Extracellular Matrix Organization Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Rhythmic Process Spleen Development Positive Regulation Of NF-kappaB Transcription Factor Activity
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	RIP-mediated NFkB activation via ZBP1 DEx/H-box helicases activate type I IFN and inflammatory cytokines production PKMTs methylate histone lysines TAK1 activates NFkB by phosphorylation and activation of IKKs complex Interleukin-1 processing SUMOylation of immune response proteins IkBA variant leads to EDA-ID Dectin-1 mediated noncanonical NF-kB signaling NIK - noncanonical NF-kB signaling The NLRP3 inflammasome TRAF6 mediated NF-kB activation Purinergic signaling in leishmaniasis infection
Drugs			Acetylsalicylic acid Glucosamine HE3286 P54 NOX-700 SGN-30 Custirsen Andrographolide
Diseases
GWAS		Blond vs. brown/black hair color ( 30531825) Blood pressure ( 21572416) Body mass index ( 26426971) Coffee consumption ( 29367735) Diastolic blood pressure ( 26390057) Esophageal cancer ( 21642993) Systolic blood pressure ( 26390057)	Metabolite levels ( 23823483) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: CSNK2A1 EIF6 FBXO7 FGF2 H2AC4 IL7R IVNS1ABP MAP3K14 MT-ND1 NFKB2 NPAS2 RPL29 SEL1L STAU1	36 interacting genes: BCL3 BTRC CHUK DDX3X DPF2 EPS8 GLG1 GTF2I HDAC4 HDAC5 IKBKB IKBKG MAP3K14 MAP3K8 MEN1 MTDH NFKB1 NFKBIA NFKBIB NFKBIE NFKBIZ NKRF NR3C1 NR5A1 PSMD11 REL RELA RELB RPL30 RPL6 RPS13 SIN3A SP1 TNIP2 TSC22D3 USP2
Entrez ID		6128	4791
HPRD ID		04745	01239
Ensembl ID		ENSG00000089009	ENSG00000077150
Uniprot IDs		A0A024RBK3 Q02878 Q8TBK5	Q00653
PDB IDs		4UG0 4V6X 5AJ0 5LKS 5T2C 6EK0 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP	1A3Q 2D96 3DO7 4OT9 5ZMC
Enriched GO Terms of Interacting Partners?
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