RPGR and SMC3

Number of citations of the paper that reports this interaction (PubMedID 16043481)
65

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		RPGR	SMC3
Description		retinitis pigmentosa GTPase regulator	structural maintenance of chromosomes 3
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding
	Biological Process	Intracellular Protein Transport Visual Perception Intraciliary Transport Response To Stimulus Cilium Assembly	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Regulation Of Mitotic Spindle Assembly
Pathways			Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)	Cornelia de Lange syndrome (CdLS)
GWAS			Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		14 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE	17 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1
Entrez ID		6103	9126
HPRD ID		02425	05829
Ensembl ID		ENSG00000156313	ENSG00000108055
Uniprot IDs		Q92834	Q9UQE7
PDB IDs		4JHN 4JHP 4QAM
Enriched GO Terms of Interacting Partners?
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