SMC3 and ESCO2

Number of citations of the paper that reports this interaction (PubMedID 30779731)
1

Data Source:
BioGRID (enzymatic study)

		SMC3	ESCO2
Description		structural maintenance of chromosomes 3	establishment of sister chromatid cohesion N-acetyltransferase 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole	Chromatin XY Body Nucleoplasm Chromosome Golgi Apparatus Chromocenter Cell Junction Nuclear Pericentric Heterochromatin Site Of Double-strand Break
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	Lysine N-acetyltransferase Activity, Acting On Acetyl Phosphate As Donor Acetyltransferase Activity Metal Ion Binding
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Regulation Of Mitotic Spindle Assembly	Hematopoietic Progenitor Cell Differentiation Regulation Of DNA Replication Double-strand Break Repair Sister Chromatid Cohesion Post-translational Protein Acetylation Protein Localization To Chromatin
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Establishment of Sister Chromatid Cohesion
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)	ESCO2-related disorders, including: Roberts syndrome; SC phocomelia syndrome
GWAS		Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)
Interacting Genes		17 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1	8 interacting genes: MCM2 MCM4 MCM5 MCM6 MCM7 MMS22L PCNA SMC3
Entrez ID		9126	157570
HPRD ID		05829	18564
Ensembl ID		ENSG00000108055	ENSG00000171320
Uniprot IDs		Q9UQE7	Q56NI9
PDB IDs
Enriched GO Terms of Interacting Partners?
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