RPGR and DCTN2

Number of citations of the paper that reports this interaction (PubMedID 16043481)
65

Data Source:
HPRD (in vivo)

		RPGR	DCTN2
Description		retinitis pigmentosa GTPase regulator	dynactin subunit 2
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Outer Segment Golgi Apparatus Centrosome Ciliary Basal Body Sperm Flagellum	Kinetochore Cell Cytoplasm Centrosome Cytosol Dynactin Complex Microtubule Membrane Dynein Complex Growth Cone Vesicle Extracellular Exosome
	Molecular Function	RNA Binding Guanyl-nucleotide Exchange Factor Activity Protein Binding	Motor Activity Protein Binding Protein Kinase Binding Spectrin Binding Identical Protein Binding
	Biological Process	Intracellular Protein Transport Visual Perception Intraciliary Transport Response To Stimulus Cilium Assembly	G2/M Transition Of Mitotic Cell Cycle ER To Golgi Vesicle-mediated Transport Mitotic Spindle Organization Mitotic Metaphase Plate Congression Regulation Of G2/M Transition Of Mitotic Cell Cycle Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Melanosome Transport Protein Localization To Centrosome Ciliary Basal Body-plasma Membrane Docking
Pathways			MHC class II antigen presentation Regulation of PLK1 Activity at G2/M Transition HSP90 chaperone cycle for steroid hormone receptors (SHR) Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane COPI-mediated anterograde transport COPI-independent Golgi-to-ER retrograde traffic AURKA Activation by TPX2
Drugs
Diseases		Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD) Retinitis pigmentosa (RP)
GWAS
Interacting Genes		14 interacting genes: DCTN1 DCTN2 HOMEZ IFT88 KIF3A KIFAP3 NPM1 PDE6D RPGRIP1 SLC25A10 SMC1A SMC3 TUBG1 YWHAE	22 interacting genes: BICD1 BICD2 BLOC1S6 CALM1 CCDC172 DISC1 EGFR GADD45A GNAO1 GOLM1 GRB2 GSK3B HAUS1 HGS KIFC3 KPNA2 MAPK6 MAPRE3 MARCKSL1 PAFAH1B1 RPGR ZW10
Entrez ID		6103	10540
HPRD ID		02425	09568
Ensembl ID		ENSG00000156313	ENSG00000175203
Uniprot IDs		Q92834	A0A384MDU9 A8K8J9 B3KTX4 Q13561 V9HW58
PDB IDs		4JHN 4JHP 4QAM
Enriched GO Terms of Interacting Partners?
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