SMC3 and MXI1

Number of citations of the paper that reports this interaction (PubMedID 9528857)
6

Data Source:
HPRD (in vitro)

		SMC3	MXI1
Description		structural maintenance of chromosomes 3	MAX interactor 1, dimerization protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Chromatin Lateral Element Nucleoplasm Chromosome Cytosol Cohesin Complex Nuclear Matrix Meiotic Cohesin Complex Nuclear Meiotic Cohesin Complex Mitotic Spindle Pole	Nuclear Chromatin Nucleus Nucleoplasm Nucleolus Cytosol RNA Polymerase II Transcription Factor Complex
	Molecular Function	Chromatin Binding Microtubule Motor Activity Protein Binding ATP Binding Mediator Complex Binding Protein Heterodimerization Activity Beta-tubulin Binding Dynein Complex Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Protein Binding Protein Dimerization Activity
	Biological Process	Mitotic Cell Cycle Regulation Of DNA Replication DNA Repair Sister Chromatid Cohesion Stem Cell Population Maintenance Cell Division Meiotic Cell Cycle Regulation Of Mitotic Spindle Assembly	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Proliferation Cytoplasmic Sequestering Of Transcription Factor
Pathways		Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression
Drugs
Diseases		Cornelia de Lange syndrome (CdLS)
GWAS		Lumbar spine bone mineral density (integral) ( 27476799) Metabolite levels ( 23823483)	Birth weight ( 31043758) Diastolic blood pressure ( 30224653) Neutrophil count ( 29403010) Normalized brain volume ( 19010793) Platelet count ( 29403010) White blood cell count ( 29403010)
Interacting Genes		17 interacting genes: APC CEP63 DISC1 ESCO2 ESR1 FEZ1 FEZ2 KIFAP3 MTNR1B MXD1 MXD3 MXD4 MXI1 RPGR SMC1A SMC1B TRAF3IP1	18 interacting genes: APP CALCOCO2 ENTPD5 KRT40 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 MAX MYC NOTCH2NLA RPL23AP32 SIN3A SIN3B SMARCB1 SMC3 USHBP1
Entrez ID		9126	4601
HPRD ID		05829	02486
Ensembl ID		ENSG00000108055	ENSG00000119950
Uniprot IDs		Q9UQE7	A0A0S2Z3X5 P50539
PDB IDs
Enriched GO Terms of Interacting Partners?
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