REL and TNIP2

Number of citations of the paper that reports this interaction (PubMedID 26186194)
367

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		REL	TNIP2
Description		REL proto-oncogene, NF-kB subunit	TNFAIP3 interacting protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol I-kappaB/NF-kappaB Complex	Nucleoplasm Cytosol
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding	Protein Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neuron Death	Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Protein Deubiquitination CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways		Activation of NF-kappaB in B cells	MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases
Drugs
Diseases		Hodgkin lymphoma
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 22412388 21102463) Erectile dysfunction ( 30583798) Hodgkin's lymphoma ( 21037568 24920014) Inflammatory bowel disease ( 23128233) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 22170493) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Ulcerative colitis ( 20228799)	Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244)
Interacting Genes		212 interacting genes: A1CF AAAS ACBD4 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 ALOX5 AR ARIH2 ARNT2 ASAP3 ATG9A ATPAF2 ATXN1 BANP BARHL2 BBS4 BID BMF C11orf68 C12orf75 C1orf109 C9orf72 CABP5 CALM1 CCNE1 CCNJL CDKN2C CENPX CEP19 CGGBP1 CHAF1A CHCHD2 CIB3 CINP CKS1B CLIC4 COL20A1 COL8A1 CPNE2 CPSF1 CTNNBIP1 CXCL14 DAAM2 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EIF3A EIF3D EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EML2 EP300 EPHB6 EPM2AIP1 EXOSC1 EXOSC5 EXOSC8 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FOXO4 FUT11 GADD45G GLYCTK GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPLL HSPA4 HSPA8 HSPB7 IL36RN KIAA0100 KLHL32 KLHL40 KRTAP9-4 LASP1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MEMO1 MIEN1 MLIP MOGS MORF4L1 MRPL10 MTPN MVP NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NOL9 NOTCH1 NR2C2AP NUCB1 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PAK1IP1 PARVG PATE1 PGAP6 PIH1D2 PLCB4 PLEKHN1 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAB2 PRKN PSMA1 PTGER3 PTK6 R3HDM2 RAB41 RABIF RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 S100A1 SAT1 SDCBP SEC14L4 SEC31A SEPTIN7 SIN3A SLC39A13 SLC41A3 SLC6A12 SNRNP25 SP1 SRF STK16 SZT2 TBP TDO2 TLE5 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRIM27 TRIM74 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBE2K UBE2Z VPS25 YARS1 ZDHHC24 ZNF417 ZNF550 ZNF564 ZNF572 ZNF688 ZNF765	25 interacting genes: APP CDKN1A CLK1 EP300 FBXO25 FLNA IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NDUFB9 NFKB1 NFKB2 PSMD9 REL RELA SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC
Entrez ID		5966	79155
HPRD ID		01286	18207
Ensembl ID		ENSG00000162924	ENSG00000168884
Uniprot IDs		Q04864	D6RGJ2 Q8NFZ5
PDB IDs			5H07
Enriched GO Terms of Interacting Partners?
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