REL and FHIT

Number of citations of the paper that reports this interaction (PubMedID 24722188)
51

Data Source:
BioGRID (two hybrid)

		REL	FHIT
Description		REL proto-oncogene, NF-kB subunit	fragile histidine triad diadenosine triphosphatase
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol I-kappaB/NF-kappaB Complex	Fibrillar Center Cytoplasm Mitochondrion Cytosol Plasma Membrane
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding	Nucleotide Binding Catalytic Activity Protein Binding Hydrolase Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Bis(5'-adenosyl)-triphosphatase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neuron Death	Purine Nucleotide Metabolic Process Nucleotide Metabolic Process Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Pathways		Activation of NF-kappaB in B cells
Drugs			Adenosine Monotungstate Fructose Ado-P-Ch2-P-Ps-Ado
Diseases		Hodgkin lymphoma	Non-small cell lung cancer Small cell lung cancer
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 22412388 21102463) Erectile dysfunction ( 30583798) Hodgkin's lymphoma ( 21037568 24920014) Inflammatory bowel disease ( 23128233) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 22170493) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Ulcerative colitis ( 20228799)	Adverse response to lamotrigine and phenytoin ( 22379998) Aortic root size ( 21223598) Asparaginase-induced acute pancreatitis in acute lymphoblastic leukemia (onset time) ( 27114598) Asperger disorder ( 21182207) Attention deficit hyperactivity disorder ( 18821565) Autism spectrum disorder or schizophrenia ( 28540026) Blood pressure ( 24954895) Blood protein levels ( 30072576) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28552196 26961502 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Broad depression or schizophrenia ( 30626913) Bronchopulmonary dysplasia ( 23897914) Caudal anterior-cingulate cortex volume ( 31530798) Cognitive function ( 25644384) Conotruncal heart defects ( 24800985) Depressive symptom measurement or major depressive disorder ( 28049566) Differentiated thyroid cancer ( 28703219) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hip circumference ( 28552196) Intracranial aneurysm ( 29531279) Iris color (L* coordinate) ( 30895295) Irritable bowel syndrome ( 29673008) Lung function (maximal voluntary ventilation) ( 29095316) Major coronary event in cardiovascular disease (time to event) (darapladib treatment interaction) ( 28753643) Major coronary event in placebo-treated cardiovascular disease (time to event) ( 28753643) Major depressive disorder ( 20125088) Methadone dose in opioid dependence ( 28115739) Myopia (pathological) ( 23049088) Orofacial clefts ( 22419666) Papillary thyroid cancer ( 28703219) Pars triangularis volume ( 31530798) Photic sneeze reflex ( 27182965) Postoperative myocardial infarction after cardiac surgery ( 30678657) Response to amphetamines ( 22952603) Response to citalopram treatment ( 22760553) Schizophrenia ( 30285260) Urinary metabolite levels in chronic kidney disease ( 29545352) Waist circumference ( 28552196) Weight ( 28552196)
Interacting Genes		212 interacting genes: A1CF AAAS ACBD4 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 ALOX5 AR ARIH2 ARNT2 ASAP3 ATG9A ATPAF2 ATXN1 BANP BARHL2 BBS4 BID BMF C11orf68 C12orf75 C1orf109 C9orf72 CABP5 CALM1 CCNE1 CCNJL CDKN2C CENPX CEP19 CGGBP1 CHAF1A CHCHD2 CIB3 CINP CKS1B CLIC4 COL20A1 COL8A1 CPNE2 CPSF1 CTNNBIP1 CXCL14 DAAM2 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EIF3A EIF3D EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EML2 EP300 EPHB6 EPM2AIP1 EXOSC1 EXOSC5 EXOSC8 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FOXO4 FUT11 GADD45G GLYCTK GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPLL HSPA4 HSPA8 HSPB7 IL36RN KIAA0100 KLHL32 KLHL40 KRTAP9-4 LASP1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MEMO1 MIEN1 MLIP MOGS MORF4L1 MRPL10 MTPN MVP NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NOL9 NOTCH1 NR2C2AP NUCB1 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PAK1IP1 PARVG PATE1 PGAP6 PIH1D2 PLCB4 PLEKHN1 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAB2 PRKN PSMA1 PTGER3 PTK6 R3HDM2 RAB41 RABIF RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 S100A1 SAT1 SDCBP SEC14L4 SEC31A SEPTIN7 SIN3A SLC39A13 SLC41A3 SLC6A12 SNRNP25 SP1 SRF STK16 SZT2 TBP TDO2 TLE5 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRIM27 TRIM74 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBE2K UBE2Z VPS25 YARS1 ZDHHC24 ZNF417 ZNF550 ZNF564 ZNF572 ZNF688 ZNF765	9 interacting genes: CTNNB1 FDXR GSN HSPD1 RAB40B REL SRC TRIM23 UBE2I
Entrez ID		5966	2272
HPRD ID		01286	03096
Ensembl ID		ENSG00000162924	ENSG00000189283
Uniprot IDs		Q04864	A0A024R366 P49789
PDB IDs			1FHI 1FIT 2FHI 2FIT 3FIT 4FIT 5FIT 6FIT
Enriched GO Terms of Interacting Partners?
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