TNIP2 and MAP3K8

Number of citations of the paper that reports this interaction (PubMedID 15169888)
33

Data Source:
HPRD (in vitro, in vivo)

		TNIP2	MAP3K8
Description		TNFAIP3 interacting protein 2	mitogen-activated protein kinase kinase kinase 8
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GO Annotations	Cellular Component	Nucleoplasm Cytosol	Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein Kinase Binding Polyubiquitin Modification-dependent Protein Binding Metal Ion Binding K63-linked Polyubiquitin Modification-dependent Protein Binding	Magnesium Ion Binding Protein Serine/threonine Kinase Activity MAP Kinase Kinase Kinase Activity Protein Binding ATP Binding
	Biological Process	Apoptotic Process Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Protein Deubiquitination CD40 Signaling Pathway Toll-like Receptor 2 Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Transcription By RNA Polymerase II Protein Stabilization Positive Regulation Of B Cell Activation Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Negative Regulation Of Endothelial Cell Apoptotic Process	Activation Of MAPKK Activity Protein Phosphorylation Cell Cycle Regulation Of Mitotic Cell Cycle Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade T Cell Costimulation Activation Of Protein Kinase Activity Stress-activated MAPK Cascade Interleukin-1-mediated Signaling Pathway
Pathways		MAP3K8 (TPL2)-dependent MAPK1/3 activation Ovarian tumor domain proteases	CD28 dependent PI3K/Akt signaling MAP3K8 (TPL2)-dependent MAPK1/3 activation MAP3K8 (TPL2)-dependent MAPK1/3 activation
Drugs
Diseases
GWAS		Extrinsic epigenetic age acceleration ( 29374233) Multiple sclerosis ( 31604244)	Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908 23128233) Systemising ( 31508503) Ulcerative colitis ( 28067908)
Interacting Genes		25 interacting genes: APP CDKN1A CLK1 EP300 FBXO25 FLNA IKBKG MAP3K8 MAPK1 MKNK1 NCOR2 NDUFB9 NFKB1 NFKB2 PSMD9 REL RELA SMARCD1 SMURF1 SRPK2 STK11 TEK TNFAIP3 TSG101 UBC	17 interacting genes: ACY3 AKT1 BMPR2 CD40 CHUK MAP2K1 MAP2K4 MAP3K14 NFKB1 NFKB2 REL RELA RIPK1 STIP1 TNIP2 TRAF2 TRAF6
Entrez ID		79155	1326
HPRD ID		18207	01863
Ensembl ID		ENSG00000168884	ENSG00000107968
Uniprot IDs		D6RGJ2 Q8NFZ5	P41279 Q6FG25
PDB IDs		5H07	4Y83 4Y85 5IU2
Enriched GO Terms of Interacting Partners?
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