REL and FHL2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		REL	FHL2
Description		REL proto-oncogene, NF-kB subunit	four and a half LIM domains 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex Cytosol I-kappaB/NF-kappaB Complex	Nucleus Nucleoplasm Focal Adhesion Z Disc M Band
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Identical Protein Binding Metal Ion Binding Androgen Receptor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Inflammatory Response I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Gene Expression Negative Regulation Of Interferon-beta Production Cellular Response To Stress Response To Cytokine NIK/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Neuron Death	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Response To Hormone Regulation Of Lipid Metabolic Process Androgen Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Heart Trabecula Formation Negative Regulation Of Calcineurin-NFAT Signaling Cascade
Pathways		Activation of NF-kappaB in B cells	PPARA activates gene expression
Drugs
Diseases		Hodgkin lymphoma
GWAS		Celiac disease ( 20190752) Celiac disease and Rheumatoid arthritis ( 26546613) Crohn's disease ( 22412388 21102463) Erectile dysfunction ( 30583798) Hodgkin's lymphoma ( 21037568 24920014) Inflammatory bowel disease ( 23128233) Psoriasis ( 25903422 20953190 25574825 23143594) Psoriasis vulgaris ( 26626624) Psoriatic arthritis ( 26626624 22170493) Rheumatoid arthritis ( 30423114 23143596 24390342 20453842 19503088) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Ulcerative colitis ( 20228799)	Body fat mass ( 28552196) Household income (MTAG) ( 31844048) Lung cancer in ever smokers ( 28604730) Pulse pressure ( 30224653 30578418)
Interacting Genes		212 interacting genes: A1CF AAAS ACBD4 ACOT8 ACTN3 ADRB2 ADSL AGPAT4 ALOX5 AR ARIH2 ARNT2 ASAP3 ATG9A ATPAF2 ATXN1 BANP BARHL2 BBS4 BID BMF C11orf68 C12orf75 C1orf109 C9orf72 CABP5 CALM1 CCNE1 CCNJL CDKN2C CENPX CEP19 CGGBP1 CHAF1A CHCHD2 CIB3 CINP CKS1B CLIC4 COL20A1 COL8A1 CPNE2 CPSF1 CTNNBIP1 CXCL14 DAAM2 DGCR6 DHPS DMRT3 DNTT DPF2 DYNC1LI1 EFHC1 EIF3A EIF3D EIF4E2 EIF4EBP1 EIF5A EIF5A2 ELF1 EML2 EP300 EPHB6 EPM2AIP1 EXOSC1 EXOSC5 EXOSC8 FHIT FHL2 FKBP1B FLAD1 FLNA FNDC11 FOXO4 FUT11 GADD45G GLYCTK GRB2 GTF2B HAT1 HDAC7 HIP1 HLA-DOA HNRNPLL HSPA4 HSPA8 HSPB7 IL36RN KIAA0100 KLHL32 KLHL40 KRTAP9-4 LASP1 LGALS14 LMO1 LMO2 LNPEP LSM2 MAD2L2 MAGOHB MAP3K7CL MAP3K8 MAPK8 MEMO1 MIEN1 MLIP MOGS MORF4L1 MRPL10 MTPN MVP NAGK NCK2 NDE1 NDUFAF3 NECAP1 NEDD9 NEIL2 NEUROG3 NFKB1 NFKB2 NFKBIA NFKBIB NFKBIE NGB NKRF NME7 NOL9 NOTCH1 NR2C2AP NUCB1 NUDT14 NXT2 OAZ3 OSGIN1 OSTF1 OTUB2 OTUD4 PAK1IP1 PARVG PATE1 PGAP6 PIH1D2 PLCB4 PLEKHN1 POLE2 POLR1A POLR2L POP5 PPP4C PRDM10 PRKAB2 PRKN PSMA1 PTGER3 PTK6 R3HDM2 RAB41 RABIF RASSF5 RBM39 RECK RELA REXO1L6P RIPPLY1 RNF213 RNF6 RSPH14 S100A1 SAT1 SDCBP SEC14L4 SEC31A SEPTIN7 SIN3A SLC39A13 SLC41A3 SLC6A12 SNRNP25 SP1 SRF STK16 SZT2 TBP TDO2 TLE5 TMEM165 TMEM268 TNIP2 TNS2 TRAPPC2L TRIM27 TRIM74 TSPOAP1 TSSC4 TSSK3 TSTD2 TTC19 TTC21A TXNL4B UBASH3A UBE2K UBE2Z VPS25 YARS1 ZDHHC24 ZNF417 ZNF550 ZNF564 ZNF572 ZNF688 ZNF765	98 interacting genes: ADAM17 AK1 APP AR ARHGAP9 ATXN1 BANP BIN1 BLZF1 BMPR2 BRCA1 CAPN1 CARD8 CCDC92 CKM CREBBP CSK CSN2 CTNNB1 DCP1A DPF2 DTX2 DUSP10 E2F1 E2F2 E2F3 E2F4 EP300 ESR1 FHL1 FHL3 FHL5 FOXO1 GLYR1 GNG12 HAND1 HCK HSPB2 ID3 IDH1 IER3 IGFBP5 IKZF4 INCA1 ITGA3 ITGA7 ITGB1 ITGB2 ITGB5 ITGB6 JUP KANK2 KIAA1217 MCM7 MDM2 MYBPC1 NIBAN1 NRF1 PFKM PHB2 PSEN2 PUF60 RAI2 REL REV1 RFX3 RUNX2 SAP30BP SAXO1 SFPQ SIGLEC6 SLC34A1 SMAD2 SMAD3 SMAD4 SP2 SRF STAT3 SUMO1P1 TNFRSF11A TRAF6 TRIM55 TRIM63 TTN WT1 ZBTB16 ZBTB25 ZFP64 ZFYVE9 ZMYM4 ZNF131 ZNF212 ZNF3 ZNF331 ZNF408 ZNF417 ZNF626 ZNF638
Entrez ID		5966	2274
HPRD ID		01286	04026
Ensembl ID		ENSG00000162924	ENSG00000115641
Uniprot IDs		Q04864	Q14192 Q2XQU9 Q6I9R8
PDB IDs			1X4K 1X4L 2D8Z 2MIU
Enriched GO Terms of Interacting Partners?
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