RAD51D and PRDM14

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		RAD51D	PRDM14
Description		RAD51 paralog D	PR/SET domain 14
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Telomeric Region Nuclear Chromosome, Telomeric Region Nucleus Nucleoplasm Replication Fork Cytoplasm Centrosome Rad51B-Rad51C-Rad51D-XRCC2 Complex	Nucleus Nucleoplasm
	Molecular Function	Four-way Junction DNA Binding DNA Binding Single-stranded DNA Binding Protein Binding ATP Binding DNA-dependent ATPase Activity Gamma-tubulin Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding Methyltransferase Activity Chromatin DNA Binding Sequence-specific DNA Binding Metal Ion Binding
	Biological Process	Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Repair Reciprocal Meiotic Recombination Interstrand Cross-link Repair Strand Invasion Regulation Of Cell Cycle	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Cell Fate Specification Inner Cell Mass Cell Fate Commitment Germ Cell Development Embryo Implantation Fertilization Germ-line Stem Cell Population Maintenance Histone H3-R26 Methylation Somatic Stem Cell Population Maintenance Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of DNA Methylation Homeostasis Of Number Of Cells Within A Tissue Inactivation Of Paternal X Chromosome Positive Regulation Of Flagellated Sperm Motility Positive Regulation Of Stem Cell Population Maintenance
Pathways		HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes	Transcriptional regulation of pluripotent stem cells
Drugs
Diseases
GWAS			Schizophrenia ( 30285260) Testicular germ cell tumor ( 28604728 28604732 23666240)
Interacting Genes		22 interacting genes: AMOTL2 BLM C1orf94 CCDC33 CEP57L1 EFHC2 IHO1 IKZF1 IKZF3 KIFC3 KRT15 LNX1 LZTS2 PRDM14 RAD51B RAD51C RHOU RNF138 SWSAP1 XRCC2 XRCC3 ZSWIM7	32 interacting genes: AKAP9 ATPAF2 BAG4 BCAR3 BEX2 CASP8 CDCA7L CHEK2 DGCR6 EED EIF4E2 ERBB2 EZH2 GPATCH2L HEXIM2 HSPB7 ID3 IDH1 MIA3 NDUFB9 PALB2 PAX2 PLEKHF2 PRKAB2 PSMA1 PTPRJ RAD51D RBM10 RCOR3 SUZ12 TEKT4 TTC32
Entrez ID		5892	63978
HPRD ID		04261	11457
Ensembl ID		ENSG00000185379	ENSG00000147596
Uniprot IDs		O75771	Q9GZV8
PDB IDs		2KZ3
Enriched GO Terms of Interacting Partners?
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