CHD8 and ASH2L

Number of citations of the paper that reports this interaction (PubMedID 24705355)
15

Data Source:
BioGRID (two hybrid)

		CHD8	ASH2L
Description		chromodomain helicase DNA binding protein 8	ASH2 like, histone lysine methyltransferase complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Protein-containing Complex MLL1 Complex	Nucleus Nucleoplasm Nuclear Euchromatin Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding	Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding Euchromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly
Pathways		Deactivation of the beta-catenin transactivating complex	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases
GWAS		Height ( 31562340)	Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)
Interacting Genes		10 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 TOP3B WDR5	25 interacting genes: BARD1 BRCA1 CHD8 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1
Entrez ID		57680	9070
HPRD ID		16712	05309
Ensembl ID		ENSG00000100888	ENSG00000129691
Uniprot IDs		Q9HCK8	B4DPT1 F5H8F7 Q9UBL3
PDB IDs		2CKA 2DL6	3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ
Enriched GO Terms of Interacting Partners?
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