CHD8 and RBBP5

Number of citations of the paper that reports this interaction (PubMedID 24705355)
15

Data Source:
BioGRID (two hybrid)

		CHD8	RBBP5
Description		chromodomain helicase DNA binding protein 8	RB binding protein 5, histone lysine methyltransferase complex subunit
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Protein-containing Complex MLL1 Complex	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	P53 Binding DNA Binding DNA Helicase Activity Chromatin Binding Protein Binding ATP Binding Beta-catenin Binding DNA-dependent ATPase Activity Methylated Histone Binding Histone Binding Armadillo Repeat Domain Binding	Protein Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II In Utero Embryonic Development Brain Development Wnt Signaling Pathway DNA Duplex Unwinding Social Behavior ATP-dependent Chromatin Remodeling Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Transcription By RNA Polymerase III Digestive Tract Development Prepulse Inhibition Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Fibroblast Apoptotic Process	Cellular Response To DNA Damage Stimulus Response To Estrogen Post-translational Protein Modification Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly
Pathways		Deactivation of the beta-catenin transactivating complex	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation
Drugs
Diseases
GWAS		Height ( 31562340)	Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 28240269) Mean platelet volume ( 24026423)
Interacting Genes		10 interacting genes: AR ASH2L CHD7 CREB1 CTCF CTNNB1 RBBP5 RCHY1 TOP3B WDR5	11 interacting genes: ASH2L CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 RB1 UBE2I
Entrez ID		57680	5929
HPRD ID		16712	02826
Ensembl ID		ENSG00000100888	ENSG00000117222
Uniprot IDs		Q9HCK8	A0A024R9B5 B4DLF8 Q15291
PDB IDs		2CKA 2DL6	3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?