ASH2L and RBBP5

Number of citations of the paper that reports this interaction (PubMedID 26886794)
38

Data Source:
BioGRID (pull down)

		ASH2L	RBBP5
Description		ASH2 like, histone lysine methyltransferase complex subunit	RB binding protein 5, histone lysine methyltransferase complex subunit
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Nucleoplasm Nucleolus Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex
	Molecular Function	Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding Euchromatin Binding	Protein Binding Methylated Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly	Cellular Response To DNA Damage Stimulus Response To Estrogen Post-translational Protein Modification Regulation Of Megakaryocyte Differentiation Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function Neddylation
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)	Basophil percentage of granulocytes ( 27863252) Blood protein levels ( 28240269) Mean platelet volume ( 24026423)
Interacting Genes		25 interacting genes: BARD1 BRCA1 CHD8 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1	11 interacting genes: ASH2L CHD8 CTBP1 CTNNB1 H3-4 H3C14 KMT2A KMT2B MEN1 RB1 UBE2I
Entrez ID		9070	5929
HPRD ID		05309	02826
Ensembl ID		ENSG00000129691	ENSG00000117222
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	A0A024R9B5 B4DLF8 Q15291
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ	3P4F 4X8N 4X8P 5F6K 5F6L 6KIU 6KIV 6KIW 6KIX 6KIZ 6KM7
Enriched GO Terms of Interacting Partners?
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