ASH2L and DNMT3L

Number of citations of the paper that reports this interaction (PubMedID 24952347)
9

Data Source:
BioGRID (pull down)

		ASH2L	DNMT3L
Description		ASH2 like, histone lysine methyltransferase complex subunit	DNA methyltransferase 3 like
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Cytosol ESC/E(Z) Complex
	Molecular Function	Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding Euchromatin Binding	Protein Binding Enzyme Activator Activity Enzyme Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly	DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Male Meiosis I Spermatogenesis DNA Methylation On Cytosine DNA Methylation Involved In Gamete Generation Positive Regulation Of Catalytic Activity Negative Regulation Of Transcription, DNA-templated Stem Cell Differentiation Negative Regulation Of DNA Methylation Positive Regulation Of DNA Methylation
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	DNA methylation
Drugs
Diseases
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)
Interacting Genes		25 interacting genes: BARD1 BRCA1 CHD8 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1	77 interacting genes: - ASH2L ATF1 ATF2 ATF3 ATF4 BLZF1 CDX2 CREB1 CREBL2 CREM DDIT3 DLX4 DMTF1 DNMT3A DNMT3B DR1 E2F3 E2F5 E2F6 EGR1 EGR2 EGR4 ESR1 ESR2 ETS1 F2RL1 FOS FOSB FOSL1 FOSL2 GATA1 GMEB1 GSK3B GTF2H2 GTF2I GTF3C5 H2AC20 H2BC21 H3C14 H4C14 HAND1 HAND2 HDAC1 HNF4G HOXA5 HOXC11 ID1 JUN JUNB KLF12 LDB1 LHX2 MAFK MECP2 MED7 MEF2A MEF2D NFIL3 NFKB1 NR1H2 NR1I2 NR1I3 NR2E1 NR3C1 NR6A1 NUDT21 PHPT1 RELA RSL24D1 RXRA SMAD1 SMAD3 SMAD4 TLE5 TP53 YY1
Entrez ID		9070	29947
HPRD ID		05309	09417
Ensembl ID		ENSG00000129691	ENSG00000142182
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	Q9UJW3
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ	2PV0 2PVC 2QRV 4U7P 4U7T 5YX2 6BRR 6F57
Enriched GO Terms of Interacting Partners?
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