ASH2L and KMT2D

Number of citations of the paper that reports this interaction (PubMedID 16603732)
72

Data Source:
BioGRID (pull down, pull down, affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro)

		ASH2L	KMT2D
Description		ASH2 like, histone lysine methyltransferase complex subunit	lysine methyltransferase 2D
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nuclear Euchromatin Histone Methyltransferase Complex MLL3/4 Complex Set1C/COMPASS Complex MLL1 Complex	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex
	Molecular Function	Protein Binding Beta-catenin Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding Euchromatin Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Transcription Coactivator Activity Protein Binding Histone Binding Histone Methyltransferase Activity (H3-K4 Specific) Transcription Regulatory Region DNA Binding Metal Ion Binding
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Cellular Response To DNA Damage Stimulus Positive Regulation Of Cell Proliferation Hemopoiesis Response To Estrogen Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Histone H3-K4 Methylation Beta-catenin-TCF Complex Assembly	Oocyte Growth Chromatin Silencing Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway Response To Estrogen Histone H3-K4 Dimethylation Regulation Of Megakaryocyte Differentiation Positive Regulation Of Transcription By RNA Polymerase II Oogenesis Histone H3-K4 Methylation Histone H3-K4 Trimethylation Histone H3-K4 Monomethylation Beta-catenin-TCF Complex Assembly
Pathways		Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function	Formation of the beta-catenin:TCF transactivating complex PKMTs methylate histone lysines Deactivation of the beta-catenin transactivating complex Activation of anterior HOX genes in hindbrain development during early embryogenesis RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs
Diseases			Kabuki syndrome
GWAS		Menopause (age at onset) ( 22267201) Schizophrenia ( 29483656)	Chronotype ( 30696823) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Intelligence (MTAG) ( 29326435)
Interacting Genes		25 interacting genes: BARD1 BRCA1 CHD8 CTNNB1 DNMT3L DPY30 EP300 H3-4 H3C1 KMT2A KMT2B KMT2D KMT2E MEN1 PPP1CC PRMT1 RBBP5 SMAD9 SMURF1 SMURF2 TGFBR1 TP53 UNC119 WWP1 ZSCAN1	9 interacting genes: AKT1 ASH2L CTNNB1 ESR1 H3C14 MEN1 POLR2A SMAD1 SMAD9
Entrez ID		9070	8085
HPRD ID		05309	03664
Ensembl ID		ENSG00000129691	ENSG00000167548
Uniprot IDs		B4DPT1 F5H8F7 Q9UBL3	O14686 Q59FG6 Q6PIA1
PDB IDs		3RSN 3S32 3TOJ 4RIQ 4X8N 4X8P 5F6K 5F6L 6E2H 6KIU 6KIV 6KIW 6KIX 6KIZ	3UVK 4ERQ 4Z4P 6O7G
Enriched GO Terms of Interacting Partners?
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