CCDC146 and MED4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		CCDC146	MED4
Description		coiled-coil domain containing 146	mediator complex subunit 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Centriole	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex
	Molecular Function	Protein Binding	Transcription Coregulator Activity Protein Binding Nuclear Receptor Transcription Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated
Pathways			PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases
GWAS		Body mass index ( 28892062) Response to amphetamines ( 22952603)	Thiopurine-induced acute severe leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced early leukopenia in Crohn's disease ( 25108385) Thiopurine-induced leukopenia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe alopecia in inflammatory bowel disease ( 29923122) Thiopurine-induced severe leukopenia in inflammatory bowel disease ( 29923122)
Interacting Genes		33 interacting genes: CBY2 CCDC136 CCNDBP1 CEP170P1 CEP44 DTNBP1 GOLGA2 KRT18 KRT19 KRT38 KRT40 MAGEA11 MAGEA6 MED4 MTUS2 NECAB2 NINL NUP62 PDE4DIP PNMA1 PSMC6 RINT1 RNF40 RPGRIP1 TFIP11 TNR TPM3 TRAF1 TRIM23 TRIM54 TSC22D4 USHBP1 VPS52	33 interacting genes: AMOT AP2M1 ATF7IP C1orf216 CCDC146 CCHCR1 CTDP1 CTNNBL1 FAM13C FOXJ3 FRMD6 FTCD HAUS1 KIFC3 LRRFIP1 MAB21L3 MCRS1 MED30 MED9 NDE1 PCBD2 PUM2 SDCBP SDCBP2 SGF29 SMARCD1 SMARCE1 SSX3 TLE5 TNFAIP8 TXLNA USHBP1 WDTC1
Entrez ID		57639	29079
HPRD ID		11150	16145
Ensembl ID		ENSG00000135205	ENSG00000136146
Uniprot IDs		Q8IYE0 Q96MS1	A0A024RDY7 Q9NPJ6
PDB IDs
Enriched GO Terms of Interacting Partners?
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